{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:22:51Z","timestamp":1777875771764,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The prevalence and clinical significance of\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      detection of anti-thyroglobulin antibodies (TgAbs) during the follow-up of patients with differentiated thyroid cancer (DTC) is unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We utilized the National Thyroid Cancer Treatment Cooperative Study registry (1987\u20132012). Patients registered after 1996 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093318) were analyzed. We identified 1545 subjects who had available TgAb status (TgAb cohort) between years 1996 and 2012, of whom 1325 were TgAb negative at first postoperative follow-up testing. From this initial TgAb-negative group, we excluded 513 patients: 423 patients who had less than 3 years of follow-up and\/or fewer than three follow-up visits, 86 patients with persistent disease after initial treatment, and 4 patients with data entry errors. The remaining 812 patients were included for analysis, comprising the TgAb persistently negative group (defined as TgAb negative for at least 3 consecutive follow-up visits and at least 3 years of follow-up) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009772) and the\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb-positive group in whom TgAbs became detectable (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200940). We then assessed whether\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      appearance of TgAb was associated with DTC structural recurrence by using the Kaplan\u2013Meier method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      detection of TgAb occurred in 5% of DTC patients. Recurrence of DTC in the TgAb persistently negative group compared with the\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb-positive group did not differ significantly (9.6% vs. 15.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.23). Baseline characteristics, histology, history of radiation exposure, staging, and median duration of follow-up were similar between the two groups. Interestingly, in all six patients who suffered a recurrence in the\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb-positive group, the TgAbs were negative at the time of recurrence detection and became positive at a median of 2.1 (0.7\u20138.7) years after the structural recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Utilizing a large North American DTC registry, we found the prevalence of\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb detection to be 5% among initially TgAb-negative patients. We did not find a statistically significant association between\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb development and DTC structural recurrence. Larger prospective studies are required to confirm these findings and further assess the significance of\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      TgAb detection in the follow-up of DTC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0791","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T04:14:22Z","timestamp":1585628062000},"page":"1490-1495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The\n                    <i>De Novo<\/i>\n                    Detection of Anti-Thyroglobulin Antibodies and Differentiated Thyroid Cancer Recurrence"],"prefix":"10.1177","volume":"30","author":[{"given":"Ngwe","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, University of California, San Francisco (Fresno Medical Education Program), Fresno, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven I.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngju","family":"Pak","sequence":"additional","affiliation":[{"name":"The Lundquist Institute, Torrance, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle R.","family":"Litofsky","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Gianoukakis","sequence":"additional","affiliation":[{"name":"The Lundquist Institute, Torrance, California, USA."},{"name":"Division of Endocrinology, Diabetes and Metabolism, Harbor-UCLA Medical Center, Torrance, and David Geffen School of Medicine at UCLA, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the National Thyroid Cancer Treatment Cooperative Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth B.","family":"Ain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Thomas","family":"Bigos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Brierley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry G.","family":"Fein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan R.","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Jonklaas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Ladenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry R.","family":"Maxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S.A.","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas S.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica C.","family":"Skarulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Steward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501993"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.435"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.07.003"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0698"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0962"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01592.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01940"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.431"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0606"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0450"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.737"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980901)83:5<1012::AID-CNCR28>3.0.CO;2-9"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-8-199810150-00007"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.1229"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0407"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0062"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2864"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2015-1346"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000103"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-36-6-1088"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1251"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1390498"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63642-5"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00574.x"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1199"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2725"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2019.0791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:06:57Z","timestamp":1777586817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2019.0791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1089\/thy.2019.0791"],"URL":"https:\/\/doi.org\/10.1089\/thy.2019.0791","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}