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The database contents are updated here with the same website (\n                    <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/tsh-receptor-mutation-database.org\">tsh-receptor-mutation-database.org<\/jats:uri>\n                    ). The new database contains 638 cases of\n                    <jats:italic toggle=\"yes\">TSHR<\/jats:italic>\n                    mutations: 448 cases of gain of function mutations (7 novel mutations and 41 new cases for previously described mutations since its last update in 2012) and 190 cases of loss of function mutations (28 novel mutations and 31 new cases for previously described mutations since its last update in 2012). This database is continuously updated and allows for rapid validation of patient\n                    <jats:italic toggle=\"yes\">TSHR<\/jats:italic>\n                    mutations causing hyper- or hypothyroidism or insensitivity to TSH.\n                  <\/jats:p>","DOI":"10.1089\/thy.2019.0807","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T02:25:35Z","timestamp":1582943135000},"page":"931-935","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Thyrotropin Receptor Mutation Database Update"],"prefix":"10.1177","volume":"30","author":[{"given":"Alexandra","family":"Stephenson","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Lau","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Eszlinger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paschke","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Section of Endocrinology and Metabolism, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada."},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30380"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2017.04.005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3290"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0313"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-073"},{"key":"e_1_3_3_7_2","unstructured":"Eszlinger M SA Stewardson P McIntyre JB Paschke R 2018 84% Prevalence of TSHR and Gsa Mutations in 207 HTA Samples based on targeted NGS at High Depth. 88th Annual Meeting of the American Thyroid Association Washington DC Mary Ann Liebert Inc Thyroid."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.12.4441"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1767"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072502320908277"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.13"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01848-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.108437"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0069"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.1009"},{"key":"e_1_3_3_17_2","unstructured":"Bircan Rea 2005 The Second Follicular Thyroid Carcinoma Presenting as a Hot Nodule with a Somatic I486F TSH-Receptor (TSHR) Gene Mutation. 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