{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:23:11Z","timestamp":1777875791658,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Deborah Doniach MD, FRCP was born in Geneva, Switzerland in 1912. She attended high school at the Lyc\u00e9e Moli\u00e8re and medical school at the Sorbonne in Paris. Deborah married Israel (Sonny) Doniach in 1933. After the births of their two children, she resumed her studies at the Royal Free Hospital Medical School in London, graduating in 1945. After additional training in Immunopathology and Endocrinology, Dr. Doniach joined the faculty in the Department of Immunology at the Middlesex Hospital and rose to become Honorary Consultant Immunopathologist and full Professor of Clinical Immunology. During her career, Deborah enjoyed a long and fruitful collaboration with the chemist and immunologist Ivan Roitt. From their partnership sprang the seminal discovery that Hashimoto's thyroiditis is an autoimmune disease in which circulating antibodies target thyroglobulin, a normal thyroid protein. In addition, they demonstrated a separate antibody cytotoxic to thyrocytes, later found to target thyroid peroxidase. These novel insights ran counter to the prevailing scientific dogma contending that antibodies target only nonself antigens. Thus, the field of research into thyroid autoimmunity, and indeed into autoimmune diseases in general, was born. This work spawned a cadre of future investigators whose studies define our current understanding of thyroid autoimmunity and the broader spectrum of autoimmune disease. In her private life, Deborah was a free thinker who defied conventional norms of the day. She was vivacious, warm, and genuinely interested in everybody and everything. Deborah Doniach died on New Year's Day, 2004 at the age of 91.<\/jats:p>","DOI":"10.1089\/thy.2020.0124","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T02:20:14Z","timestamp":1587176414000},"page":"942-947","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Deborah Doniach: Discovering Thyroid Autoimmunity: The End of Horror Autotoxicus"],"prefix":"10.1177","volume":"30","author":[{"given":"Rebecca","family":"Bahn","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabitha","family":"Doniach","sequence":"additional","affiliation":[{"name":"Family Practice, Sutter Medical Group of the Redwoods, Santa Rosa, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"351","article-title":"Deborah Doniach","volume":"328","author":"Richmond C","year":"2004","unstructured":"Richmond C. 2004. Deborah Doniach. BMJ, 328:351.","journal-title":"BMJ"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15809-1"},{"key":"e_1_3_4_4_2","unstructured":"European Thyroid Association. 2004. Milestones in European Thyroidology\u2014Deborah Doniach (1912\u20132004). Available at https:\/\/www.eurothyroid.com\/about\/met\/doniach.html (accessed April2 2020)."},{"key":"e_1_3_4_5_2","unstructured":"The Guardian Newspaper. 2004. Deborah Doniach: Outstanding Pioneer of Auto-immunology Research. Available at https:\/\/www.theguardian.com\/society\/2004\/jan\/15\/health.obituaries (accessed April2 2020)."},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.37.020186.002033"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916938808997171"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1957.10"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0130070"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1969.8"},{"key":"e_1_3_4_11_2","first-page":"307","article-title":"Fluorescent antibody studies in human thyroiditis: auto-antibodies to an antigen of the thyroid colloid distinct from thyroglobulin","volume":"42","author":"Balfour BM","year":"1961","unstructured":"Balfour BM, , Doniach D, , Roitt IM, , Couchman KG. 1961. Fluorescent antibody studies in human thyroiditis: auto-antibodies to an antigen of the thyroid colloid distinct from thyroglobulin. Br J Exp Pathol, 42:307\u2013316.","journal-title":"Br J Exp Pathol"},{"key":"e_1_3_4_12_2","unstructured":"Ehrlich P. 1906 Collected Studies on Immunity 2nd ed. Wiley New York p 388."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/86280"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.76.6.417"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.76.6.408"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5020.672"},{"key":"e_1_3_4_17_2","unstructured":"Welcome Witnesses to Contemporary Medicine. 1997. Self and Non-self: A History of Autoimmunity. Available at https:\/\/archive.org\/details\/wellcomewitnesses?sort=-reviewdate&&and[]=year%3A%221997%22 (accessed April2 2020)."},{"key":"e_1_3_4_18_2","first-page":"820","article-title":"Auto-antibodies in Hashimoto's disease (lymphadenoid goitre)","volume":"271","author":"Campbell PN","year":"1956","unstructured":"Campbell PN, , Doniach D, , Hudson RV, , Roitt IM. 1956. Auto-antibodies in Hashimoto's disease (lymphadenoid goitre). Lancet, 271:820\u2013821.","journal-title":"Lancet"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-17-11-1293"},{"key":"e_1_3_4_20_2","first-page":"11","article-title":"Abnormal responses in the assay of thyrotropin","volume":"34","author":"Adams DD","year":"1956","unstructured":"Adams DD, , Purves HD. 1956. Abnormal responses in the assay of thyrotropin. Proc Univ Otago Med Sch, 34:11\u201312.","journal-title":"Proc Univ Otago Med Sch"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.2.342"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-24-10-1005"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104579"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)90161-8"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)92401-8"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-1-11-856"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.16.6735"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5555"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-3-724"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5316.1347"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90140-8"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.126.2.277"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-5-972"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/289594a0"},{"key":"e_1_3_4_35_2","first-page":"727","article-title":"A reassessment of studies on the aggregation of thyroid autoimmunity in families of thyroiditis patients","volume":"2","author":"Roitt IM","year":"1967","unstructured":"Roitt IM, , Doniach D. 1967. A reassessment of studies on the aggregation of thyroid autoimmunity in families of thyroiditis patients. Clin Exp Immunol, 2:727\u2013736.","journal-title":"Clin Exp Immunol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5257.909"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5342.1374"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.14.6.654"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2020.0124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2020.0124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2020.0124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:07:20Z","timestamp":1777586840000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2020.0124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1089\/thy.2020.0124"],"URL":"https:\/\/doi.org\/10.1089\/thy.2020.0124","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}