{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:17:36Z","timestamp":1780568256265,"version":"3.54.1"},"reference-count":67,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Little is known about the application of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. This meta-analysis was aimed to investigate the use of TBSRTC in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant articles were searched in PubMed and Web of Science. Meta-analysis of proportion and its 95% confidence interval (CI) were computed utilizing the random-effect model. We used subgroup analyses and meta-regression to explore the sources of heterogeneities. Egger's regression test and funnel plot visualization were used to examine publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 17 articles comprising of 3687 pediatric thyroid nodules for meta-analyses. TBSRTC outputs including frequency and risk of malignancy (ROM) for the majority of categories were not statistically different from recently published meta-analysis of 145,066 thyroid nodules in adult patients. The resection rate (RR) in the pediatric group was significantly higher in most of the categories compared with published adult data: benign, 23.2% [CI\u2009=\u200918.6\u201327.9] vs. 13.0% [CI\u2009=\u20099.5\u201316.5]; atypia of undetermined significance\/follicular lesion of undetermined significance, 62.6% [CI\u2009=\u200950.3\u201374.9] vs. 36.2% [CI\u2009=\u200929.9\u201342.5]; follicular neoplasm\/suspicious for follicular neoplasm, 84.3% [CI\u2009=\u200975.2\u201393.4] vs. 60.5% [CI\u2009=\u200954.5\u201366.5]; and suspicious for malignancy, 93.8% [CI\u2009=\u200990.1\u201397.6] vs. 69.7% [CI\u2009=\u200964.0\u201375.5].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TBSRTC is a valuable tool to make clinical decisions for pediatric patients with thyroid nodules. Pediatric patients with benign and indeterminate thyroid nodules had a higher RR than adult counterpart, but ROM of these categories in adults and children was not statistically different suggesting a potential risk of overtreatment in pediatric patients. Determining the best treatment guidelines and additional tools for risk stratification must be a top priority to precisely identify the target patient groups for surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2020.0702","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T01:05:00Z","timestamp":1611795900000},"page":"1203-1211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["The Use of the Bethesda System for Reporting Thyroid Cytopathology in Pediatric Thyroid Nodules: A Meta-Analysis"],"prefix":"10.1177","volume":"31","author":[{"given":"Huy Gia","family":"Vuong","sequence":"first","affiliation":[{"name":"Department of Pathology; Oklahoma City, Oklahoma, USA."},{"name":"Stephenson Cancer Center; Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy Giang Bao","family":"Chung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Minh","family":"Ngo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien Quoc","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Hassell","sequence":"additional","affiliation":[{"name":"Department of Pathology; Oklahoma City, Oklahoma, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Kwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennichi","family":"Kakudo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Bychkov","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kameda Medical Center, Kamogawa, Japan."},{"name":"Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21605"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22228"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3926"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0460"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0287"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24935"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-015-3855-0"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13285"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9470-y"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.07.022"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22104"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21400"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0728"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23265"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_5_22_2","first-page":"405","article-title":"Cytological classification of thyroid nodules. Proposal of the SIAPEC-IAP Italian Consensus Working Group","volume":"102","author":"Fadda G","year":"2010","unstructured":"Fadda G, , Basolo F, , Bondi A, , Bussolati G, , Crescenzi A, , Nappi O, , Nardi F, , Papotti M, , Taddei G, , Palombini L. 2010. Cytological classification of thyroid nodules. Proposal of the SIAPEC-IAP Italian Consensus Working Group. Pathologica, 102:405\u2013408.","journal-title":"Pathologica"},{"key":"e_1_3_5_23_2","first-page":"335","article-title":"Confidence interval or p-value?: part 4 of a series on evaluation of scientific publications","volume":"106","author":"du Prel J-B","year":"2009","unstructured":"du Prel J-B, , Hommel G, , R\u00f6hrig B, , Blettner M. 2009. Confidence interval or p-value?: part 4 of a series on evaluation of scientific publications. Dtsch Arztebl Int, 106:335\u2013339.","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.60.2.170"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39343.408449.80"},{"key":"e_1_3_5_27_2","unstructured":"National Heart Lung and Blood Institute (NHLBI) 2014. Quality assessment tool for observational cohort and cross-sectional studies. Available at https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools (accessed June20 2020)."},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i2.78"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21750"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0427"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0596-OA"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2018-0476"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.333"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21199"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.046"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.190451"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21713"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03507-4"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.06.011"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/AJCP\/AQAA182"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-2151"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1796"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2017.10.006"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00552"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0191"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.45.203"},{"key":"e_1_3_5_47_2","first-page":"211","article-title":"Psychosocial issues in pediatric oncology","volume":"12","author":"Marcus J","year":"2012","unstructured":"Marcus J. 2012. Psychosocial issues in pediatric oncology. Ochsner J, 12:211\u2013215.","journal-title":"Ochsner J"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsp056"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0330"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz113"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0104"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.03.098"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21933"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0506"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0502"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","unstructured":"Ngo HTT Nguyen TPX Vu TH Jung CK Hassell L Kakudo K Vuong HG 2020 Impact of molecular testing on the management of indeterminate thyroid nodules among Western and Asian countries: a systematic review and meta-analysis. Endocr Pathol [Epub ahead of print]; DOI: 10.1007\/s12022-020-09643-0.","DOI":"10.1007\/s12022-020-09643-0"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0059"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0312"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa573"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032224"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0594"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13912"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000351029"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10043"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22309"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12491"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP161208.GL"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00882"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2020.0702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2020.0702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2020.0702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:07:57Z","timestamp":1777586877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2020.0702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1089\/thy.2020.0702"],"URL":"https:\/\/doi.org\/10.1089\/thy.2020.0702","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}