{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:24:12Z","timestamp":1777875852509,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Thyroid lobectomy reduces risks of surgical complications and need for levothyroxine (LT4). We aimed at identifying the clinical course and risk factors for postlobectomy hypothyroidism to optimize surgical counseling and management in pediatric patients undergoing lobectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical and biochemical presentations pre- and postlobectomy were retrospectively reviewed for 110 patients who underwent thyroid lobectomy between 2008 and 2020 at the Children's Hospital of Philadelphia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Approximately 28.2% of patients (31\/110) developed postlobectomy hypothyroidism defined by an elevated thyrotropin (TSH) level, including 24.5% (27\/110) with subclinical hypothyroidism (TSH &gt;4.5 and &lt;10.0 mIU\/L) and 3.6% (4\/110) with overt hypothyroidism (TSH &gt;10.0 mIU\/L). LT4 was initiated in 12.7% (14\/110) of cases. Most patients (81.6%; 84\/103) recovered euthyroidism within 12 months postlobectomy. When excluding patients with autonomous nodule(s), median preoperative TSH was 1.09 (interquartile range [IQR]\u2009=\u20090.70\u20131.77) mIU\/L and 1.80 (IQR\u2009=\u20091.02\u20132.68) mIU\/L in euthyroid and hypothyroid patients, respectively, with multivariate logistic regression confirming the association between an increased preoperative TSH and postlobectomy hypothyroidism (odds ratio\u2009=\u20091.8 [confidence interval 1.08\u20133.13],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.024). Of the patients who underwent thyroid lobectomy and developed postoperative hypothyroidism (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200931), 38.7% (12\/31) had a preoperative diagnosis of an autonomously functioning thyroid nodule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Thyroid function should be evaluated postlobectomy to assess the need for LT4. LT4 should be considered if the TSH remains elevated, especially if an upward trend is observed or TSH is &gt;10.0 mIU\/L. Suppressed preoperative TSH associated with autonomous nodules is an independent risk factor for postlobectomy hypothyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2021.0396","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T10:34:19Z","timestamp":1635503659000},"page":"1786-1793","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Course of Early Postoperative Hypothyroidism Following Thyroid Lobectomy in Pediatrics"],"prefix":"10.1177","volume":"31","author":[{"given":"Julia A.","family":"Baran","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-881X","authenticated-orcid":false,"given":"Andrew J.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Halada","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sogol","family":"Mostoufi-Moab","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."},{"name":"Division of Pediatric Oncology; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Isaza","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Robbins","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aime T.","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Scott","family":"Adzick","sequence":"additional","affiliation":[{"name":"Department of Surgery; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-6071","authenticated-orcid":false,"given":"Tasleema","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Thyroid Center; Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-9151","authenticated-orcid":false,"given":"Ken","family":"Kazahaya","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3597"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1779"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0460"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2224-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.06.026"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1063"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/313971"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/1658-631X.194243"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4174\/jkss.2011.81.6.380"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02410-5"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00396"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.10.1076"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00520"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1627-1"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.619841"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5743-9"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2019.01.015"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3997"},{"key":"e_1_3_4_21_2","unstructured":"Bernal J 2000 Thyroid hormones in brain development and function. In: Feingold KR Anawalt B Boyce A Chrousos G de Herder WW Dungan K Grossman A Hershman JM Hofland J Kaltsas G Koch C Kopp P Korbonits M McLachlan R Morley JE New M Purnell J Singer F Stratakis CA Trence DL Wilson DP (eds) Endotext [Internet]. South Dartmouth MA: MDText.com Inc."},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.07.037"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.038"},{"key":"e_1_3_4_24_2","first-page":"237","article-title":"Effects of thyroid status on bone metabolism: a primary role for thyroid stimulating hormone or thyroid hormone?","volume":"30","author":"Galliford TM","year":"2005","unstructured":"Galliford TM, , Murphy E, , Williams AJ, , Bassett JH, , Williams GR. 2005. Effects of thyroid status on bone metabolism: a primary role for thyroid stimulating hormone or thyroid hormone?. 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