{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:01:10Z","timestamp":1787162470517,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The usual inverse correlation between thyrotropin (TSH) and thyroid hormone disappears in syndromes of central resistance to thyroid hormone, where both are high. TSH and thyroid hormone are also simultaneously high when there is an elevation of the set point of the thyroid regulation axis. This can be estimated with indices, such as the Parametric Thyroid Feedback Quantile-based Index (PTFQI), which was designed for the general population. The PTFQI is positively associated with diabetes prevalence, but association with other pathologies has not been yet explored. The aim of this project was to explore the potential relationship of the PTFQI with metabolic and cardiovascular disease in a sample of ambulatory adult patients from Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was carried out among the patients who underwent thyroid hormones measurement (6434 measurements from September to November 2018 in a central laboratory in Spain). We retrospectively reviewed clinical records of a subgroup of adults aged &gt;18 years with normal TSH and free thyroxine (fT4) belonging to groups that represent extreme PTFQI (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009661). Individuals with known conditions interfering the thyroid axis were excluded (remaining\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009296). Logistic and linear regression models adjusted for age and sex were used to calculate odds ratio (OR) of diseases and differences of clinical parameters, and 95% confidence intervals [CI].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Across levels with higher PTFQI, there was an increase in the prevalence of type 2 diabetes (High vs. Low PTFQI OR: 2.88 [CI: 1.14\u20137.86],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Trend\u2009=\u20090.02), ischemic heart disease (16.4% vs. 0%, unadjusted Haldane\u2013Anscombe corrected OR: 23.90 [CI: 1.36\u201321.48], adjusted\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Trend\u2009=\u20090.04), atrial fibrillation (OR: 8.13 [CI: 1.33\u2013158.20],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Trend\u2009=\u20090.05), and hypertension (OR: 3.19 [CI: 1.14\u20139.94],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Trend\u2009=\u20090.05). While the prevalence of type 2 diabetes was similarly associated with TSH and fT4, ischemic heart disease, atrial fibrillation, and hypertension were more strongly associated with the differences in fT4 values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Type 2 diabetes, ischemic heart disease, atrial fibrillation, and hypertension may be associated with a higher central regulation set point for thyroid hormone. These findings should be confirmed in other populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2022.0025","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T01:17:41Z","timestamp":1658884661000},"page":"1488-1499","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["A Cross-Sectional Study Examining the Parametric Thyroid Feedback Quantile Index and Its Relationship with Metabolic and Cardiovascular Diseases"],"prefix":"10.1177","volume":"32","author":[{"given":"Vanesa","family":"Alonso-Ventura","sequence":"first","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Civeira","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"CIBERCV-ISCIII, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almendra","family":"Alvarado-Rosas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Lou-Bonafonte","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, Zaragoza, Spain."},{"name":"CIBEROBN-ISCIII, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Calmarza","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"CIBERCV-ISCIII, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Moreno-Franco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"CIBERCV-ISCIII, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jesus","family":"Andres-Otero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa, IIS Arag\u00f3n, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Calvo-Gracia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa, IIS Arag\u00f3n, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"de Diego-Garcia","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Laclaustra","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, IIS Arag\u00f3n, Zaragoza, Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Zaragoza, Spain."},{"name":"Facultad de Medicina, Universidad de Zaragoza, Spain."},{"name":"CIBERCV-ISCIII, Madrid, 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