{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:58:38Z","timestamp":1790690318516,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Given the paucity of epidemiological studies on thyroid storm, we aimed to estimate the incidence rate and case fatality of thyroid storm in Germany based on a large claims database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Using the German Pharmacoepidemiological Research Database (GePaRD) we identified patients with at least one inpatient discharge diagnosis of thyroid storm (\n                      <jats:italic toggle=\"yes\">International Statistical Classification of Diseases and Related Health Problems<\/jats:italic>\n                      , 10th revision, German modification; ICD-10-GM E05.5) between 2007 and 2017 and calculated age-standardized and age-specific incidence rates in males and females (no age restriction). We defined deaths occurring within 30 days of the diagnosis as thyroid storm-associated and determined case fatality by sex and age group. Point estimates were reported with confidence intervals [CIs].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified 1690 patients with an incident diagnosis of thyroid storm. Of these, 72% were females (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091212). The mean age was 60 years (standard deviation: 18.6 years). The age-standardized incidence rate per 100,000 persons per year was 1.4 [CI 1.2\u20131.7] in females and 0.7 [CI 0.5\u20130.9] in males. In females \u226460 and &gt;60 years of age, the incidence rate was 0.9 [CI 0.9\u20131.0] (males: 0.4 [CI 0.3\u20130.4]) and 2.7 [CI 2.5\u20132.9] (males: 1.7 [CI 1.5\u20131.9]), respectively. The case fatality of thyroid storm was 1.4% [CI 0.6\u20132.8] in females \u226460 years and 10.9% [CI 8.6\u201313.7] in females &gt;60 years. In males, the case fatality was 1.0% [CI 0.2\u20134.0] in those aged \u226460 years and 16.7% [CI 12.6\u201321.7] in those &gt;60 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Incidence rates of thyroid storm were markedly higher in females than in males and were three times higher in persons &gt;60 years compared with younger age groups. The case fatality was below 2% in persons aged \u226460 years and markedly higher in older persons (males: 17 times and females: 8 times).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2022.0096","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T10:36:31Z","timestamp":1661423791000},"page":"1307-1315","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Estimating Incidence and Case Fatality of Thyroid Storm in Germany Between 2007 and 2017: A Claims Data Analysis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-1599","authenticated-orcid":false,"given":"Arulmani","family":"Thiyagarajan","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-7978","authenticated-orcid":false,"given":"Katharina","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-7353","authenticated-orcid":false,"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-399X","authenticated-orcid":false,"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-2923","authenticated-orcid":false,"given":"Ulrike","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany."},{"name":"Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30165-8"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0334"},{"key":"e_1_3_6_4_2","article-title":"Thyroid Storm","author":"Pokhrel B","year":"2020","unstructured":"Pokhrel B, , Aiman W, , Bhusal K. 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