{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:51:00Z","timestamp":1790139060498,"version":"4.0.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Studies have shown that thyroid autoimmunity (TAI) is associated with increased risks of adverse pregnancy outcomes. The aim of this study was to investigate the associations between TAI and embryo quality in euthyroid women undergoing\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      fertilization or intracytoplasmic sperm injection (IVF\/ICSI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included euthyroid infertile women with and without TAI (defined as a serum thyroperoxidase concentration \u226534 IU\/mL or a thyroglobulin concentration \u2265115.0 IU\/mL) who underwent their first complete IVF\/ICSI treatment cycles at a tertiary referral center between April 2016 and February 2022. Embryo quality measurements and clinical outcomes were compared between women with (TAI positive) and without TAI (TAI negative). The high-quality cleavage embryo rate and cumulative live birth rate (cLBR) were the primary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 499 TAI-positive and 2945 TAI-negative women were included in this study, and their mean (standard deviation) ages were 31.6 (4.5) and 30.9 (4.4) years, respectively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). The overall analysis showed no significant differences between TAI-negative and TAI-positive women in the high-quality cleavage embryo rate (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \/\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      : 11,139\/22,553 vs. 1971\/3820; adjusted rate: 52.8% vs. 53.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.66) and cLBR (1917\/2945 vs. 327\/499; 53.4% vs. 56.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.31). Moreover, no significant differences were observed between TAI-negative and TAI-positive women in the rates of oocyte retrieval (35,078\/51,978 vs. 5853\/8628; 69.1% vs. 69.4%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.65), fertilization (23,067\/34,197 vs. 3902\/5728; 61.1% vs. 62.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.34), embryo utilization (18,233\/22,553 vs. 3156\/3820; 80.2% vs. 80.8%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.61), blastocyst formation (7051\/13,721 vs. 1192\/2330; 48.5% vs. 48.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.97), and high-quality blastocysts (4819\/13,721 vs. 799\/2330; 29.9% vs. 29.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.73). Furthermore, no significant differences were observed between TAI-negative and TAI-positive women in the clinical pregnancy rate (1524\/2808 vs. 248\/482; 46.7% vs. 44.6%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.40), early pregnancy loss rate (156\/1524 vs. 23\/248; 13.5% vs. 11.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.44), and LBR (1338\/2808 vs. 218\/482; 37.4% vs. 36.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.55) of the first transfer cycle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrated that TAI in women was not associated with embryo quality or the cLBR following IVF\/ICSI. Future large studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2022.0184","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T06:41:20Z","timestamp":1672036880000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Thyroid Autoimmunity Is Not Associated with Embryo Quality or Pregnancy Outcomes in Euthyroid Women Undergoing Assisted Reproductive Technology in China"],"prefix":"10.1177","volume":"33","author":[{"given":"Meng","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of General Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunmei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-4140","authenticated-orcid":false,"given":"Shuhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-3253","authenticated-orcid":false,"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0457"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0031"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00671-3"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2616"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw034"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10931"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.003"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.03.011"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex033"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0657"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.698579"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02633"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.18249"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812537"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000512790"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00961.x"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3467"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0041-0"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1442427"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0567"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0154"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199906000-00013"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.07.1068"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez238"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.04.029"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0049"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev263"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey108"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz003"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8598-9"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2016.02.004"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1704"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1296424"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0529-0"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12220"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1092513"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0077"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0309"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.01.015"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew027"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0562"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2022.0184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2022.0184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2022.0184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:09:28Z","timestamp":1777586968000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2022.0184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1089\/thy.2022.0184"],"URL":"https:\/\/doi.org\/10.1089\/thy.2022.0184","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}