{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:35:39Z","timestamp":1790253339755,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anaplastic thyroid carcinoma (ATC) is a rare and frequently fatal type of thyroid cancer. The degree of heterogeneity in survival rates for ATC is incompletely studied. This study evaluated the factors associated with overall survival (OS) of patients with ATC using multicenter real-world data from a national tertiary care center network in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this multicenter, retrospective cohort study, all patients with ATC diagnosed between 2010 and 2020 were identified from the national database of the French ENDOCAN-TUTHYREF network. Factors associated with OS were examined in multivariable analyses using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 360 patients. Of these, 220 (61%) were female and the median age was 72 years (interquartile range: 62\u201380). The percentages of patients with pure and mixed (synchronously-transformed) ATC (p-ATC and st-ATC) were 62.5% and 26.7%, respectively. The median OS was 6.8 months [confidence interval, CI: 5.5\u20138.1]: not reached for stage IVa, 11.4 months [8.2\u201317.8] for IVb, and 4.6 months [3.5\u20135.7] for IVc. Surgery, radiation therapy to the neck, chemotherapy, and best supportive care were administered to 69 (19.2%), 214 (59.4%), 254 (70.6%), and 66 (18.3%) patients, respectively. In a multivariable analysis, including stage IVb\u2013IVc patients, significantly higher OS was observed in patients with Eastern Cooperative Oncology Group performance-status of 0\u20131 (hazard ratio [HR], 0.6; [CI, 0.4\u20130.9],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.02), stage IVb [HR, 0.5; CI, 0.4\u20130.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001], and multimodal treatment (surgery and chemoradiotherapy) [HR, 0.07; CI, 0.04\u20130.1,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. Variables associated with significantly worse OS included: p-ATC (vs. st-ATC) [HR, 1.83; CI, 1.33\u20132.51,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001] and a neutrophil-to-lymphocyte ratio (NLR) &gt;5.05 [HR, 2.05, CI, 1.39\u20133.05,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Factors independently associated with improved OS in ATC included: European Cooperative Oncology Group performance status, disease stage, multimodality treatment, synchronously transformed ATC, and lower NLR. Long-term OS was observed in selected patients with ATC who underwent multimodal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2023.0164","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:24:46Z","timestamp":1694006686000},"page":"1190-1200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Factors Associated with Survival in Anaplastic Thyroid Carcinoma: A Multicenter Study from the ENDOCAN-TUTHYREF Network"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4816","authenticated-orcid":false,"given":"Arnaud","family":"Jannin","sequence":"first","affiliation":[{"name":"CHU Lille, Department of Endocrinology, Diabetology, and Metabolism, Lille, France."},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER\u2014Cancer-Heterogeneity Plasticity and Resistance to Therapies, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Gustave Roussy, Paris-Saclay University, Villejuif, France."},{"name":"Oncostat, U1018, CESP, Inserm, Paris-Saclay University, \u201cLigue Contre le Cancer\u201d labeled team, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"de la Fouchardi\u00e8re","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centre L\u00e9on B\u00e9rard\/Research Center of Lyon (CRCL), UMR INSERM 1052, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Al Ghuzlan","sequence":"additional","affiliation":[{"name":"Department of Biology and Pathology, Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Wassermann","sequence":"additional","affiliation":[{"name":"Medical Oncology Department and Thyroid and Endocrine Tumors Department, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, AP-HP, IUC, Sorbonne University, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile N.","family":"Chougnet","sequence":"additional","affiliation":[{"name":"Endocrine Oncology Department, Saint-Louis Hospital (AP-HP), Universit\u00e9 Paris, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Drui","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service d'Endocrinologie-Diab\u00e9tologie et Nutrition, l'institut du thorax, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Godbert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Endocrine Oncology Department, Institute of Bergoni\u00e9, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Ilouz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, CHU Angers, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bardet","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Thyroid Unit, Center Fran\u00e7ois Baclesse, Caen, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Zanetta","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Center Georges Fran\u00e7ois Leclerc, Dijon, 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Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER\u2014Cancer-Heterogeneity Plasticity and Resistance to Therapies, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Borson Chazot","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290, EA 3738 CICLY, Universit\u00e9 Lyon 1, Claude Bernard, Lyon, France."},{"name":"Endocrinology Department, Hospice Civils de Lyon, Hospital Louis-Pradel, Bron, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-0149","authenticated-orcid":false,"given":"Christine","family":"Do Cao","sequence":"additional","affiliation":[{"name":"CHU Lille, Department of Endocrinology, Diabetology, and Metabolism, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Borget","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Gustave Roussy, Paris-Saclay University, Villejuif, France."},{"name":"Oncostat, U1018, CESP, Inserm, Paris-Saclay University, \u201cLigue Contre le Cancer\u201d labeled team, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-3289","authenticated-orcid":false,"given":"Julien","family":"Hadoux","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'imagerie, Service d'Oncologie Endocrinienne, Gustave Roussy, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ENDOCAN-TUTHYREF Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cheav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Delahaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hellal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Boudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kergoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katty","family":"Malekzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.01.011"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0574"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1437-z"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0086"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14041061"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2018.05.006"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30493"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0080"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.032"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.3362"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-004-0524-5"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24384"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20936"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20578"},{"issue":"9","key":"e_1_3_6_16_2","first-page":"5888","article-title":"The incidence and survival analysis for anaplastic thyroid cancer: A SEER database analysis","volume":"11","author":"Lin B","year":"2019","unstructured":"Lin B, , Ma H, , Ma M, et al. 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