{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:53:25Z","timestamp":1791608005379,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Background:<\/jats:title>\n Graves' disease has been associated with adverse pregnancy, labor and delivery, and neonatal outcomes. Thyroid function levels, assessed during newborn screening (NBS), can serve as indicators of the adaptation in the hypothalamic\u2013pituitary\u2013thyroid axis. We utilized data from the national thyroid NBS program to investigate the characteristics of the mother\u2013infant dyad of term infants born to mothers with past or active Graves' disease.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The dataset of the Israeli NBS for thyroid function was linked with the electronic records of a tertiary medical center to generate a unified database of mothers and their term infants born between 2011 and 2021. The MDClone big data platform extracted maternal, pregnancy, disease course, labor and delivery, and neonatal characteristics of the mother-infant dyads.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of 103,899 registered mother\u2013infant dyads, 292 (0.3%) mothers had past or active Graves' disease. A forward multivariate linear regression demonstrated that Graves' disease did not significantly affect NBS total thyroxine (tT4) levels (\n p<\/jats:italic>\n \u2009=\u20090.252). NBS tT4 levels in infants born to mothers with active Graves' disease were higher than those observed in the general Israeli population (\n p<\/jats:italic>\n \u2009<\u20090.001). Mothers with Graves' disease more frequently used assisted reproductive technology (12.7% vs. 9.0%, respectively,\n p<\/jats:italic>\n \u2009=\u20090.012; odds ratio [OR]\u2009=\u20091.46 [CI 1.03\u20132.07],\n p<\/jats:italic>\n \u2009=\u20090.031), and had more gestational hypertension (3.9% vs. 1.1%,\n p<\/jats:italic>\n \u2009<\u20090.001; OR\u2009=\u20093.53 [CI 1.92\u20136.47],\n p<\/jats:italic>\n \u2009<\u20090.001), proteinuria (2.5% vs. 0.9%,\n p<\/jats:italic>\n \u2009<\u20090.001; OR\u2009=\u20093.03 [CI 1.43\u20136.45],\n p<\/jats:italic>\n \u2009=\u20090.004), cesarean sections (26.4% vs. 19.7%,\n p<\/jats:italic>\n \u2009=\u20090.029; OR\u2009=\u20091.46 [CI 1.13\u20131.90],\n p<\/jats:italic>\n \u2009=\u20090.004), prelabor rupture of membranes (15.4% vs. 4.1%,\n p<\/jats:italic>\n \u2009<\u20090.001; OR\u2009=\u20094.3 [CI 3.13\u20135.91],\n p<\/jats:italic>\n \u2009<\u20090.001), and placental abnormalities (5.1% vs. 2.0%,\n p<\/jats:italic>\n \u2009<\u20090.001; OR\u2009=\u20092.64 [CI 1.57\u20134.44];\n p<\/jats:italic>\n \u2009<\u20090.001). Their infants had lower adjusted birthweight\n z<\/jats:italic>\n -scores (\u22120.18\u2009\u00b1\u20090.94 vs. \u22120.03\u2009\u00b1\u20090.90,\n p<\/jats:italic>\n \u2009=\u20090.007) and were more likely to be small for gestational age (12.0% vs. 8.1%,\n p<\/jats:italic>\n \u2009=\u20090.005; OR\u2009=\u20091.54 [CI 1.08\u20132.19],\n p<\/jats:italic>\n \u2009=\u20090.018).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Neonatal thyroid function levels were affected by maternal Graves' disease only when the disease was active during gestation. Moreover, maternal Graves' disease was also associated with an increased risk of adverse outcomes for the mother\u2013infant dyad.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/thy.2023.0291","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:58:08Z","timestamp":1701057488000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes in Maternal Graves' Disease: A Population-Based Mother\u2013Infant Dyad Cohort Study"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0083-9443","authenticated-orcid":false,"given":"Eyal","family":"Cohen-Sela","sequence":"first","affiliation":[{"name":"The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-8264","authenticated-orcid":false,"given":"Avivit","family":"Brener","sequence":"additional","affiliation":[{"name":"The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-4953","authenticated-orcid":false,"given":"Orian","family":"Raviv","sequence":"additional","affiliation":[{"name":"The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Yackobovitch-Gavan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Almashanu","sequence":"additional","affiliation":[{"name":"The National Newborn Screening Program, Ministry of Health, Tel-Hashomer, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronella","family":"Marom","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Neonatology, and Lis Maternity and Women's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan","family":"Anteby","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Obstetrics and Gynecology, Lis Maternity and Women's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Hiersch","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Obstetrics and Gynecology, Lis Maternity and Women's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-0574","authenticated-orcid":false,"given":"Yael","family":"Lebenthal","sequence":"additional","affiliation":[{"name":"The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, 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