{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:16Z","timestamp":1792190596112,"version":"4.4.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The rearranged during transfection (\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      ) proto-oncogene fusion is common in papillary thyroid cancer (PTC), varying across ethnic groups. However, comprehensive comparisons of\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusion types are limited. This study aims to identify predominant\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions and analyze their clinicopathological characteristics in a cohort of Chinese thyroid cancer cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This single-center retrospective cohort study analyzed thyroid cancer data, utilizing next-generation sequencing on formalin-fixed, paraffin-embedded tissue samples. Detailed clinicopathological data of thyroid cancer cases with\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 2300 thyroid cancer cases,\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions were exclusively found in PTC or differentiated high-grade thyroid carcinoma (DHGTC) cases (2234 cases), absent in other types (66 cases). Of the 2234 PTC or DHGTC cases, 113 (5.06%) exhibited\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions, including 100 primary cases. Coiled-coil domain containing 6 (\n                      <jats:italic toggle=\"yes\">CCDC6)-RET<\/jats:italic>\n                      fusions predominated (78.0%, 78\/100), with nuclear receptor coactivator 4 (\n                      <jats:italic toggle=\"yes\">NCOA4)-RET<\/jats:italic>\n                      fusions representing 22.0% (22\/100).\n                      <jats:italic toggle=\"yes\">NCOA4-RET<\/jats:italic>\n                      fusions were more prevalent in patients aged 45 years and older (54.5% vs. 28.2%,\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.021) and DHGTC cases (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05) and associated with higher rates of lymph node metastases (90.9% vs. 67.9%,\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.032).\n                      <jats:italic toggle=\"yes\">CCDC6-RET<\/jats:italic>\n                      fusion exhibited a higher prevalence of Hashimoto\u2019s thyroiditis (HT) (67.9% vs. 22.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and elevated thyroglobulin antibody levels (14.11 [1.86\u2013174.32] IU\/mL vs. 2.01 [1.14\u201315.41] IU\/mL,\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.018). Moreover,\n                      <jats:italic toggle=\"yes\">CCDC6-RET<\/jats:italic>\n                      fusion predominantly occurred in classical PTC (56.4%, 44\/78) and infiltrative follicular PTC (17.9%, 14\/78), whereas\n                      <jats:italic toggle=\"yes\">NCOA4-RET<\/jats:italic>\n                      fusion was more frequent in classical PTC (36.4%, 8\/22), solid PTC (27.3%, 6\/22), and DHGTC (27.3%, 6\/22).\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions with compound mutations were associated with older age (\u226545 years) and bilateral thyroid involvement. Follow-up data showed a higher recurrence rate in the\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusion group compared with the\n                      <jats:italic toggle=\"yes\">\n                        BRAF\n                        <jats:sup>V600E<\/jats:sup>\n                      <\/jats:italic>\n                      mutation group (5.0% vs. 0.0%,\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.018). Although the\n                      <jats:italic toggle=\"yes\">NCOA4-RET<\/jats:italic>\n                      group showed a numerically higher recurrence rate compared with\n                      <jats:italic toggle=\"yes\">CCDC6-RET<\/jats:italic>\n                      (9.1% vs. 3.8%), this difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.559).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                      fusions are specific to PTC or DHGTC cases among Chinese thyroid cancer cases.\n                      <jats:italic toggle=\"yes\">CCDC6-RET<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">NCOA4-RET<\/jats:italic>\n                      fusions exhibited distinct clinicopathological features, with\n                      <jats:italic toggle=\"yes\">NCOA4-RET<\/jats:italic>\n                      being more aggressive.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2024.0151","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:10:40Z","timestamp":1725016240000},"page":"1260-1270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinicopathological Features of\n                    <i>CCDC6-RET<\/i>\n                    and\n                    <i>NCOA4-RET<\/i>\n                    Fusions in Thyroid Cancer: A Single-Center Retrospective Cohort Study in a Chinese Population"],"prefix":"10.1177","volume":"34","author":[{"given":"Zhiting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Fudan University Shanghai Cancer Center, 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