{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:50:14Z","timestamp":1788349814109,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Medullary thyroid cancer (MTC) is a rare cancer with variable disease course. To enable optimal care, centralization and consensus guidelines are essential. This study describes trends in the incidence, organization of care, surgical treatment, and outcomes of MTC over 30 years in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients with a histological MTC diagnosis between 1989 and 2018 were identified from the Netherlands Cancer Registry and linked to the Dutch Pathology register (PALGA). Incidence rates, relative to the Dutch population, were assessed throughout time. Clinicopathological parameters and extent of lymph node (LN) surgery were extracted from PALGA pathology reports. Period A (1989\u20131998), period B (1999\u20132008), and period C (2009\u20132018) were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Throughout 30 years, the population-adjusted incidence remained stable with 0.17\u2009\u00b1\u20090.04 diagnoses per 100,000 people per year (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.247). Of all 795 patients, 54% were female and 63% were treated in an academic hospital, at a median age of 48 years (interquartile range [IQR] 34\u201361). Age at diagnosis increased over time from 42 years (IQR 25\u201361) in period A to 52 years (IQR 42\u201363) in period C (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). The proportion of treatments occurring in an academic hospital increased from 41% of patients in period A to 58% and 86% in period B and C, respectively (both\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). At primary treatment, a LN dissection was performed in 582 (73%) patients. Of these patients, 88%, 36%, and 20% underwent a central neck dissection (CND), unilateral neck dissection, and bilateral neck dissection, respectively. CND was performed more frequently in period C (93%) than in period A (77%) or B (87%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.009,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.027, respectively). Overall survival improved from period A (55%) to C (88%) and B (65%) to C (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.022,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.007, respectively). Locoregional recurrence rates remained stable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study shows a stable incidence and improved survival of MTC in the Dutch population over the last three decades. In addition, these data indicate a transition of treatment to academic hospitals, likely due to centralization, and a higher rate of CNDs, following the introduction of recommendation guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2024.0433","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:45:44Z","timestamp":1734695144000},"page":"87-96","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Trends in the Incidence, Organization of Care, and Surgical Treatment of Medullary Thyroid Cancer: A Population-Based Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Eline C.","family":"Jager","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands."},{"name":"Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon J.H.","family":"Metman","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger A.C.","family":"Timmenga","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter T.","family":"Zandee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Jansen","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettien M.","family":"van Hemel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutske","family":"Lodewijk","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno R.","family":"Vriens","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medard F.M.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton F.","family":"Engelsman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Location VUmc, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen M.A.","family":"Dreijerink","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Location VUmc, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana T.","family":"Netea-Maier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa M.","family":"van Ginhoven","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"de Heus","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thera P.","family":"Links","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The 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