{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:33:39Z","timestamp":1788791619738,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a hepatic manifestation of metabolic syndrome. This study investigated the association between newly developed nomenclature MASLD and the risk of thyroid cancer in the Korean population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>After excluding individuals with a history of liver disease or malignancy, we analyzed a cohort of 214,502 Korean adults aged 40 years and above who participated in the National Health Screening Program from 2009 to 2010. Participants were categorized into four groups: no steatotic liver disease (SLD) without a cardiometabolic risk factor (CMRF), no SLD with at least one CMRF, MASLD, and metabolic and alcohol-related\/associated liver disease (MetALD). SLD was diagnosed using a fatty liver index threshold of \u226530. The primary outcome was the diagnosis of new thyroid cancer during the follow-up period. We examined the relationship between CMRF\/SLD and thyroid cancer incidence using the multivariable-adjusted Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 2761 participants (1.3%) were newly diagnosed with thyroid cancer over an average follow-up of 9.61 years. Compared with participants without CMRF and SLD, those with CMRF (hazard ratio [HR] 1.33, confidence interval [CI] 1.16\u20131.52), those with MASLD (HR 1.36, CI 1.17\u20131.58), and the MetALD group (HR 1.40, CI 1.04\u20131.88) exhibited a significantly higher risk of thyroid cancer. In addition, MetALD is significantly associated with thyroid cancer incidence solely in men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In addition to CMRF, MASLD and MetALD were associated with a higher incidence of thyroid cancer in the Korean population. This study is the first to demonstrate the association between thyroid cancer and the CMRF-MASLD-MetALD continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2024.0522","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T10:01:29Z","timestamp":1734516089000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Thyroid Cancer"],"prefix":"10.1177","volume":"35","author":[{"given":"Sang Yi","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkook","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dong-A University College of Medicine, Busan, Republic of Korea."},{"name":"Department of Data Sciences Convergence, Dong-A University Interdisciplinary Program, Busan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hwan","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Cheol","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-966X","authenticated-orcid":false,"given":"Sunghwan","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of 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