{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:48:13Z","timestamp":1777877293489,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2010,11]]},"abstract":"\n This study evaluated profiles of immunoglobulin (Ig; IgA, IgG, IgG1, and IgG2a) response in experimental brucellosis induced with\n Brucella canis<\/jats:italic>\n in BALB\/c mice during an 8-week infection period. Six- to 8-week-old BALB\/c mice (\n n<\/jats:italic>\n \u2009=\u200936) were experimentally infected with 1\u2009\u00d7\u200910\n 9<\/jats:sup>\n CFU of\n B. canis<\/jats:italic>\n via the intraperitoneal route. Serial serum samples were collected from the mice at 0, 3, 7, 14, 21, 28, 35, 42, 49, and 56 days after inoculation. The sera were tested by the rapid slide agglutination test (RSAT) and 2-mercaptoethanol-RSAT and indirect enzyme-linked immunosorbent assay. Sera tested positive for\n B. canis<\/jats:italic>\n by the RSAT and 2-mercaptoethanol-RSAT beginning from 7 days after inoculation until the end of the experiment. The IgA response was detected at 14 days after infection and reached peak levels at 21 days after infection. The IgG antibody responses were detected at 7 days after infection and reached the peak value at 35 days after infection. Data of our study demonstrated IgG2a-dominant responses over IgG1 during the course of infection (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>","DOI":"10.1089\/vbz.2009.0125","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T21:13:44Z","timestamp":1272316424000},"page":"927-930","source":"Crossref","is-referenced-by-count":1,"title":["Immunoglobulin Profiles in Acute Brucellosis Experimentally Induced by\n Brucella canis<\/i>\n in BALB\/c Mice"],"prefix":"10.1177","volume":"10","author":[{"given":"Sung-Il","family":"Lee","sequence":"first","affiliation":[{"name":"Kansai Medical University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Ariful","family":"Islam","sequence":"additional","affiliation":[{"name":"Chonbuk National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mst. Minara","family":"Khatun","sequence":"additional","affiliation":[{"name":"Chonbuk National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu-Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Chonbuk National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Myeong","family":"Jung","sequence":"additional","affiliation":[{"name":"Chonbuk National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Kirl","family":"Baek","sequence":"additional","affiliation":[{"name":"Chonbuk National University","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibulaimu","family":"Kakoma","sequence":"additional","affiliation":[{"name":"University of Illinois","place":["Illinois"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"17","volume-title":"Techniques for the Brucellosis Laboratory","author":"Alton GG","year":"1988","unstructured":"Alton GG, , Jones LM, , Angus RD, , Verger JM. Techniques for the Brucellosis Laboratory. Paris, France: Institut National de la Recherche Agronomique, 1988; 17\u2013136."},{"key":"e_1_3_2_3_1","first-page":"703","article-title":"Canine brucellosis in a Saskatchewan kennel","volume":"49","author":"Brennan SJ","year":"2008","unstructured":"Brennan SJ, , Ngeleka M, , Philibert HM, , Forbes LB, , Allen AL. Canine brucellosis in a Saskatchewan kennel. Can Vet J, 2008; 49:703\u2013708.","journal-title":"Can Vet J"},{"key":"e_1_3_2_4_1","first-page":"579","article-title":"Characterization of a newly recognized species of Brucella responsible for infectious canine abortions","volume":"58","author":"Carmichael LE","year":"1968","unstructured":"Carmichael LE, , Bruner DW. Characterization of a newly recognized species of Brucella responsible for infectious canine abortions. 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J Infect Dev Ctries, 2009; 3:392\u2013397.","journal-title":"J Infect Dev Ctries"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.65-78.2003"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-8-656"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1993.54.07.1043"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.12.5263-5268.1996"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1001.020622"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.05.005"},{"key":"e_1_3_2_16_1","first-page":"97","volume-title":"Brucellosis: Clinical and Laboratory Aspects","author":"Young EJ","year":"1989","unstructured":"Young EJ. Clinical manifestations of human brucellosis. Young EJ, , Corbel MJ. Brucellosis: Clinical and Laboratory Aspects. Boca Raton, FL: CRC Press, 1989; 97\u2013126."}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2009.0125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2009.0125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2009.0125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:47:05Z","timestamp":1777589225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2009.0125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1089\/vbz.2009.0125"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2009.0125","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}