{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:49:45Z","timestamp":1777877385877,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    Vaccination efforts for Lyme disease prevention in humans have focused on wildlife reservoirs to target the causative agent,\n                    <jats:italic toggle=\"yes\">Borrelia burgdorferi<\/jats:italic>\n                    , for elimination in vector ticks. Multiple host species are involved in the transmission and maintenance of the bacterium, but not all host species can be vaccinated effectively. To evaluate vaccinating a subset of hosts in the context of host\u2013tick interactions, we constructed and evaluated a dynamic model of\n                    <jats:italic toggle=\"yes\">B. burgdorferi<\/jats:italic>\n                    transmission in mice. Our analyses indicate that on average, a mouse-targeted vaccine is expected to proportionally reduce infection prevalence among ticks by 56%. However, relative to mouse vaccination, human risk of exposure is dominated by the number of tick bites received per person, the proportion of tick blood meals taken from the highly reservoir-competent white-footed mouse relative to other hosts, and the average number of tick bites per mouse. Variation in these factors reduces the predictability of vaccination outcomes. Additionally, contributions of nonmouse hosts to pathogen maintenance preclude elimination of\n                    <jats:italic toggle=\"yes\">B. burgdorferi<\/jats:italic>\n                    through mouse vaccination alone. Our findings indicate that to increase the impact of wildlife vaccination, reducing tick populations by acaricide application, in addition to targeting additional reservoir-competent host species, should be employed.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2011.0731","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T09:41:24Z","timestamp":1326793284000},"page":"544-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Kimberly","family":"Tsao","sequence":"first","affiliation":[{"name":"Yale School of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durland","family":"Fish","sequence":"additional","affiliation":[{"name":"Yale School of Public Health"},{"name":"Yale Center for Ecoepidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison P.","family":"Galvani","sequence":"additional","affiliation":[{"name":"Yale School of Public Health"},{"name":"Yale Center for Ecoepidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.8.1564-1566.1987"},{"key":"e_1_3_3_3_1","first-page":"1","article-title":"Surveillance for Lyme disease\u2014United States, 1992\u20132006","volume":"57","author":"Bacon RM","year":"2008","unstructured":"Bacon RM, , Kugeler KJ, , Mead PS. 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