{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:54:10Z","timestamp":1781805250667,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>\n                    Rocky Mountain spotted fever (RMSF) is a severe illness caused by\n                    <jats:italic toggle=\"yes\">Rickettsia rickettsii<\/jats:italic>\n                    for which there is no available vaccine. We hypothesize that exposure to the highly prevalent, relatively nonpathogenic \u201c\n                    <jats:italic toggle=\"yes\">Rickettsia amblyommii<\/jats:italic>\n                    \u201d protects against\n                    <jats:italic toggle=\"yes\">R. rickettsii<\/jats:italic>\n                    challenge. To test this hypothesis, guinea pigs were inoculated with \u201c\n                    <jats:italic toggle=\"yes\">R. amblyommii<\/jats:italic>\n                    .\u201d After inoculation, the animals showed no signs of illness. When later challenged with lethal doses of\n                    <jats:italic toggle=\"yes\">R. rickettsii<\/jats:italic>\n                    , those previously exposed to \u201c\n                    <jats:italic toggle=\"yes\">R. amblyommii<\/jats:italic>\n                    \u201d remained well, whereas unimmunized controls developed severe illness and died. We conclude that \u201c\n                    <jats:italic toggle=\"yes\">R. amblyommii<\/jats:italic>\n                    \u201d induces an immune response that protects from illness and death in the guinea pig model of RMSF. These results provide a basis for exploring the use of low-virulence rickettsiae as a platform to develop live attenuated vaccine candidates to prevent severe rickettsioses.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2014.1575","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T16:36:33Z","timestamp":1406651793000},"page":"557-562","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["\u201c\n                    <i>Rickettsia amblyommii<\/i>\n                    \u201d Induces Cross Protection Against Lethal Rocky Mountain Spotted Fever in a Guinea Pig Model"],"prefix":"10.1177","volume":"14","author":[{"given":"Lucas S.","family":"Blanton","sequence":"first","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Mendell","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Walker","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Bouyer","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2007.0271"},{"key":"e_1_3_3_3_1","first-page":"33","volume-title":"Biology of Rickettsial Diseases","author":"Burgdorfer W","year":"1988","unstructured":"Burgdorfer W. 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