{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:51:52Z","timestamp":1777877512592,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    Early diagnosis and treatment of acute brucellosis cases were targeted by screening the household members of the index cases. We also aimed to describe the causal relations of brucellosis in an endemic region. A cross-sectional study was performed among household members (29 index cases, 113 household members). Brucellosis was diagnosed on the basis of clinical findings, serum agglutinin titer of \u22651\/160 in standard tube agglutination test (STA), or a positive blood culture. Index cases were defined as patients who had been admitted to the clinic on suspicion of brucellosis and then confirmed as brucellosis cases. The people who lived in the same house as the index cases were defined as household members. The risk factors for seropositivity were studied by multivariate analysis. Independent variables of gender, consuming fresh cheese, blood groups, dealing with husbandry, and contact with the placenta of infected animals were included to the model. Backward and forward selections were performed. Nineteen out of 113 (17%) screened individuals had agglutination titers \u22651\/160. The mean ages of index cases and household members were 43 years (standard deviation [SD] 18) and 29 years (SD 19), respectively. In multivariate analysis, consuming fresh cheese (odds ratio [OR]=3.1, confidence interval [CI] 1.07\u20139.68,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.049), blood group A (OR=2.6, CI 1.18\u20135.96,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.018), contact with the placenta of the infected animals (OR=3.7, CI 1.42\u20139.68,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.007), and age &gt;30 years (OR=2.8, CI 1.25\u20136.51,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.13) were found to be associated with brucellosis. In univariate analysis, the individuals with blood group B were protected from brucella infection (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.013). In conclusion, screening of the people in brucellosis-endemic areas should be considered for early diagnosis and treatment. To our knowledge, blood groups were studied for the first time by this study. Higher prevalence of brucellosis among the individuals with blood group A and less prevalence among the individuals with blood group B should be considered for further studies on pathogenesis.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2014.1723","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T14:39:44Z","timestamp":1439563184000},"page":"468-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening Household Members of Acute Brucellosis Cases in Endemic Areas and Risk Factors for Brucellosis"],"prefix":"10.1177","volume":"15","author":[{"given":"Secil","family":"Deniz","sequence":"first","affiliation":[{"name":"Haydarpasa Numune Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurcan","family":"Baykam","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Celikbas","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirin Menekse","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Kartal Dr. Lutfi Kirdar Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba Cirkin","family":"Guzel","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basak","family":"Dokuzoguz","sequence":"additional","affiliation":[{"name":"Ankara Numune Training and Research Hospital","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onder","family":"Ergonul","sequence":"additional","affiliation":[{"name":"Koc University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199106000-00003"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899004458"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2004.07.009"},{"key":"e_1_3_3_5_1","first-page":"42","article-title":"Screening of household members and contacts of patients with acute brucellosis to detect unrecognized cases","volume":"2","author":"Aminzadeh Z","year":"2010","unstructured":"Aminzadeh Z, , Farrokhi B, , Zanjani HA, , Baiati Z, et al. Screening of household members and contacts of patients with acute brucellosis to detect unrecognized cases. J Infect Dis Immun, 2010; 2:42\u201343.","journal-title":"J Infect Dis Immun"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268805003973"},{"key":"e_1_3_3_7_1","first-page":"57","volume-title":"Fourth Symposium on Zoonotic Diseases in Turkey","author":"Aydin E","year":"2012","unstructured":"Aydin E. Epidemiology of Brucella infections in Turkey. In: Fourth Symposium on Zoonotic Diseases in Turkey, Ankara, 2012:57\u201363."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01963752"},{"key":"e_1_3_3_9_1","first-page":"303","article-title":"Epidemic outbreak of 81 cases of brucellosis following the consumption of fresh cheese without pasteurization","volume":"70","author":"Castel Monsalve J","year":"1996","unstructured":"Castel Monsalve J, , Rullan JV, , Peiro Callizo EF, , Nieto-Sandoval Alcolea A. Epidemic outbreak of 81 cases of brucellosis following the consumption of fresh cheese without pasteurization. Rev Esp Salud Publica, 1996; 70:303\u2013311.","journal-title":"Rev Esp Salud Publica"},{"key":"e_1_3_3_10_1","first-page":"137","article-title":"Seroprevalence of human brucellosis in a rural area of Western Anatolia, Turkey","volume":"23","author":"Cetinkaya Z","year":"2005","unstructured":"Cetinkaya Z, , Aktepe OC, , Ciftci IH, , Demirel R. Seroprevalence of human brucellosis in a rural area of Western Anatolia, Turkey. J Health Popul Nutr, 2005; 23:137\u2013141.","journal-title":"J Health Popul Nutr"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003008"},{"key":"e_1_3_3_12_1","first-page":"113","article-title":"Relationship of blood groups to disease: Do blood group antigens have a biological role?","volume":"43","author":"Garratty G","year":"2005","unstructured":"Garratty G. Relationship of blood groups to disease: Do blood group antigens have a biological role?. Rev Med Inst Mex Seguro Soc, 2005; 43:113\u2013121.","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"e_1_3_3_13_1","first-page":"519","article-title":"Epidemiological and clinical features of brucellosis in 39 family groups","volume":"7","author":"Gotuzzo E","year":"1989","unstructured":"Gotuzzo E, , Carrillo C, , Seas C, , Guerra J, et al. Epidemiological and clinical features of brucellosis in 39 family groups. Enferm Infecc Microbiol Clin., 1989; 7:519\u2013524.","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"e_1_3_3_14_1","first-page":"1717","volume-title":"Infectious Diseases","author":"Gotuzzo E","year":"2004","unstructured":"Gotuzzo E, , Carrilla C. Brucella In: Gorbach SL, , Bartlett JG, , Blacklow NR, eds. Infectious Diseases, 3 th ed. 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Pediatr Infect Dis J, 1989; 8:79\u201382.","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00213"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268802007215"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(00)90042-8"},{"key":"e_1_3_3_21_1","first-page":"158","article-title":"Seroprevalence of Brucella in an elderly population in Mid-Anatolia, Turkey","volume":"21","author":"Sumer H","year":"2003","unstructured":"Sumer H, , Sumer Z, , Alim A, , Nur N, et al. Seroprevalence of Brucella in an elderly population in Mid-Anatolia, Turkey. J Health Popul Nutr, 2003; 21:158\u2013161.","journal-title":"J Health Popul Nutr"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-008-7022-6"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/004947550303300310"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2014.1723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2014.1723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2014.1723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:53:24Z","timestamp":1777589604000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2014.1723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1089\/vbz.2014.1723"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2014.1723","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}