{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:03:24Z","timestamp":1792627404662,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Crimean-Congo hemorrhagic fever virus is a tick-borne bunyavirus of the\n                    <jats:italic toggle=\"yes\">Nairovirus<\/jats:italic>\n                    genus that causes hemorrhagic fever in humans with high case fatality. Here, we report the development of subunit vaccines and their efficacy in signal transducer and activator of transcription 1 (STAT1) knockout mice. Ectodomains of the structural glycoproteins Gn and Gc were produced using a\n                    <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                    insect cell\u2013based expression system. A single vaccination of STAT129 mice with adjuvanted Gn or Gc ectodomains induced neutralizing antibody responses, which were boosted by a second vaccination. Despite these antibody responses, mice were not protected from a CCHFV challenge infection. These results suggest that neutralizing antibodies against CCHFV do not correlate with protection of STAT1 knockout mice.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2015.1855","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T14:37:44Z","timestamp":1450449464000},"page":"759-764","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":90,"title":["Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice"],"prefix":"10.1177","volume":"15","author":[{"given":"Jeroen","family":"Kortekaas","sequence":"first","affiliation":[{"name":"part of Wageningen University and Research Centre","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianka P.M.","family":"Vloet","sequence":"additional","affiliation":[{"name":"part of Wageningen University and Research Centre","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"McAuley","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"},{"name":"Galveston National Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Shen","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"},{"name":"Galveston National Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berend Jan","family":"Bosch","sequence":"additional","affiliation":[{"name":"Utrecht University","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Vries","sequence":"additional","affiliation":[{"name":"Utrecht University","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.M.","family":"Moormann","sequence":"additional","affiliation":[{"name":"part of Wageningen University and Research Centre","place":["Netherlands"]},{"name":"Utrecht University","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Bente","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"},{"name":"Galveston National Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01383-10"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.07.006"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.019034-0"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.6152-6161.2005"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-122"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00794-11"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091516"},{"key":"e_1_3_3_9_1","first-page":"7","article-title":"Vaccine against Crimean-Congo haemorrhagic fever virus\u2014Bulgarian input in fighting the disease","volume":"37","author":"Christova I","year":"2010","unstructured":"Christova I, , Kovacheva O, , Georgieva G, , Ivanova S, et al. Vaccine against Crimean-Congo haemorrhagic fever virus\u2014Bulgarian input in fighting the disease. Problems of Infectious Parasitic Diseases, 2010; 37:7\u20138.","journal-title":"Problems of Infectious Parasitic Diseases"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.062"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003850"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05352-11"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.6.3475-3481.1995"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir335"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.1.514-525.2006"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.034"},{"key":"e_1_3_3_17_1","unstructured":"Tkachenko EA Butenko AM Butenko SA Zaradova TI et al. Prophylactic characteristics of a protective Crimean hemorrhagic fever vaccine. In: Chumakov MP ed. Crimean Hemorrhagic Fever\u2014Materials of the 3rd Scientific-Practical Conference in Rostov-na-donu Region. USSR Moscow 1970:136\u2013138."},{"key":"e_1_3_3_18_1","first-page":"119","volume-title":"Viral Hemorrhagic Fevers","author":"Tkachenko EA","year":"1971","unstructured":"Tkachenko EA, , Butenko AM, , Badalov MY, , Zaradova TI, et al. Investigation of immunogenic activity of killed brain vaccine against Crimean hemorrhagic fevers. In: Chumakov MP, ed. Viral Hemorrhagic Fevers. Moscow, USSR: Trudi Instituta Poliomielita i Virusnykh Entsefalitov, USSR Adademy of Medical Sciences, 1971:119\u2013129."},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999003321532501"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit061"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2015.1855","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2015.1855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2015.1855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:54:24Z","timestamp":1777589664000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2015.1855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1089\/vbz.2015.1855"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2015.1855","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}