{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:05:34Z","timestamp":1779437134538,"version":"3.53.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Kyasanur Forest disease virus (KFDV) is a tick-borne\n                      <jats:italic toggle=\"yes\">Flavivirus<\/jats:italic>\n                      that causes a severe illness in humans. Disease spectrum can vary from subclinical infection to fatal cases with hemorrhagic complications. The pathology of KFDV remains incompletely understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study describes the histopathologic and immunohistochemical findings in experimentally infected infant CD-1 mice with an early passage human KFDV isolate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Acute histological changes were primarily seen in the brain. The spectrum of changes included gliosis, inflammatory response, necrosis, neural loss, and syncytium formation in mid and hind brain structures. Microscopic lesions observed in the liver were mainly necrosis and vacuolation of hepatocytes and in small intestine, prominent epithelial cell necrosis. KFDV antigens could be stained by a sensitive immunohistochemical labeling in the same organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Findings from this study are suggestive of neuropathology as the main manifestation of an early passaged human KFDV isolate. Importantly, this suggests that KFDV may be causing primarily a neurologic disease and secondary organ damage could be because of disease pathology per se. The use of primary low passage human isolates and neuropathology profile could also be more apt in developing a challenge model for testing potential antivirals and therapeutic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2015.1917","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T12:52:35Z","timestamp":1463057555000},"page":"496-498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["An Early Passage Human Isolate of Kyasanur Forest Disease Virus Shows Acute Neuropathology in Experimentally Infected CD-1 Mice"],"prefix":"10.1177","volume":"16","author":[{"given":"Atanu","family":"Basu","sequence":"first","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya","family":"Yadav","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharda","family":"Prasad","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Badole","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Patil","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra Motilal","family":"Kohlapure","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra T.","family":"Mourya","sequence":"additional","affiliation":[{"name":"National Institute of Virology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"80","volume-title":"Proceedings of the Ninth Pacific Science Congress","volume":"17","author":"Work TH","unstructured":"Work TH, , Trapido H. Kyasanur Forest disease: A new infection of man and monkeys in tropical India by a virus of the Russian spring-summer complex. In: Proceedings of the Ninth Pacific Science Congress. Vo1. 17. Public Health & Medical Sciences, 1957:80\u201383."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.Supplement_4.S854"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.05.013"},{"key":"e_1_3_4_5_2","first-page":"115","article-title":"Neurological involvement in Kysanur Forest Disease","volume":"23","author":"Wadia RS","year":"1975","unstructured":"Wadia RS. Neurological involvement in Kysanur Forest Disease. Neurol India, 1975; 23:115\u2013120.","journal-title":"Neurol India"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100301"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002934"},{"key":"e_1_3_4_8_2","first-page":"1011","article-title":"Kyasanur Forest Disease VI. Pathologic findings in three fatal human cases of Kyasanur Forest Disease","volume":"13","author":"Iyer CGS","year":"1959","unstructured":"Iyer CGS, , Rao RR, , Work TH, , Narashima Murthy DP. Kyasanur Forest Disease VI. Pathologic findings in three fatal human cases of Kyasanur Forest Disease. Ind J Med Sci, 1959; 13:1011\u20131022.","journal-title":"Ind J Med Sci"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(66)90296-3"},{"key":"e_1_3_4_10_2","first-page":"1421","article-title":"Histological changes in mice infected with Kyasanur Forest Disease virus","volume":"60","author":"Nayar M","year":"1972","unstructured":"Nayar M. Histological changes in mice infected with Kyasanur Forest Disease virus. Ind J Med Res, 1972; 60:1421\u20131426.","journal-title":"Ind J Med Res"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2015.1917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2015.1917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2015.1917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:15:28Z","timestamp":1779434128000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2015.1917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1089\/vbz.2015.1917"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2015.1917","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}