{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:27:42Z","timestamp":1792726062703,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 544 healthy, afebrile indigenous people (Orang Asli) from peninsular Malaysia for TG and SFG rickettsioses in nine rural and peri-urban settlements. The study population encompassed children, adolescents, and adults. The overall seroprevalence of rickettsiosis in the Orang Asli was 48.5%, with 27.9% seroprevalence against TG rickettsiae and 20.6% seroprevalence against SFG rickettsiae. In 7.9% of the study participants, antibodies against both rickettsial groups were found. The highest seropositivity rates against TG and SRG rickettsiae were detected in young children and adults. Overall, there were no gender differences. Seroprevalences were similar among inhabitants of different settlements, except for two localities. More studies are needed to shed more light on the ecology and risk factors for TG and SFG rickettsioses in Malaysia.<\/jats:p>","DOI":"10.1089\/vbz.2018.2391","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T15:31:13Z","timestamp":1544628673000},"page":"323-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia"],"prefix":"10.1177","volume":"19","author":[{"given":"Dennis","family":"Tappe","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Gross","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano","family":"Ngui","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Rauch","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Tee","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Ai Lian","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"99","article-title":"Murine typhus in a Malaysian village","volume":"8","author":"Brown GW","year":"1977","unstructured":"Brown GW, , Dohany AL, , Shirai A, , Gan E, et al. Murine typhus in a Malaysian village. Southeast Asian J Trop Med Public Health, 1977; 8:99\u2013103.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.311"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.4"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0199"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0719-3"},{"key":"e_1_3_3_7_1","first-page":"23","article-title":"The typhus group of diseases in Malaya. Part III: The study of the virus of the urban typhus in laboratory animals","volume":"17","author":"Lewthwaite R","year":"1936","unstructured":"Lewthwaite R, , Savoor SR. The typhus group of diseases in Malaya. Part III: The study of the virus of the urban typhus in laboratory animals. Br J Exp Pathol, 1936; 17:23\u201334.","journal-title":"Br J Exp Pathol"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/2.4.339"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-13"},{"key":"e_1_3_3_10_1","first-page":"226","article-title":"The increasing prevalence of endemic typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi","volume":"41","author":"Sekhar WY","year":"2000","unstructured":"Sekhar WY, , Devi S. The increasing prevalence of endemic typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi. Singapore Med J, 2000; 41:226\u2013231.","journal-title":"Singapore Med J"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90322-5"},{"key":"e_1_3_3_12_1","first-page":"165","article-title":"Antibody prevalence of Orientia tsutsugamushi, Rickettsia typhi and TT118 spotted fever group rickettsiae among Malaysian blood donors and febrile patients in the urban areas","volume":"34","author":"Tay ST","year":"2003","unstructured":"Tay ST, , Kamalanathan M, , Rohani MY. Antibody prevalence of Orientia tsutsugamushi, Rickettsia typhi and TT118 spotted fever group rickettsiae among Malaysian blood donors and febrile patients in the urban areas. Southeast Asian J Trop Med Public Health, 2003; 34:165\u2013170.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_3_13_1","first-page":"314","article-title":"The use of the indirect immunoperoxidase test for the serodiagnosis of rickettsial diseases in Malaysia","volume":"33","author":"Tay ST","year":"2002","unstructured":"Tay ST, , Rohani MY. The use of the indirect immunoperoxidase test for the serodiagnosis of rickettsial diseases in Malaysia. Southeast Asian J Trop Med Public Health, 2002a; 33:314\u2013320.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_3_14_1","first-page":"772","article-title":"Isolation and PCR detection of rickettsiae from clinical and rodent samples in Malaysia","volume":"33","author":"Tay ST","year":"2002","unstructured":"Tay ST, , Rohani MY, , Ho TM, , Devi S. Isolation and PCR detection of rickettsiae from clinical and rodent samples in Malaysia. Southeast Asian J Trop Med Public Health, 2002b; 33:772\u2013779.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.73"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0794"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2018.2391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2018.2391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2018.2391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:58:18Z","timestamp":1777589898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2018.2391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1089\/vbz.2018.2391"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2018.2391","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,25]]}}}