{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:54:35Z","timestamp":1777877675817,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    The Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is the major cause of viral encephalitis worldwide. An investigation of mosquito species diversity, JEV infection rate, and seasonal population fluctuations of\n                    <jats:italic toggle=\"yes\">Culex tritaeniorhynchus<\/jats:italic>\n                    in Huaihua County, Hunan Province, China, revealed the distribution of vector mosquito populations and genotypes and molecular characteristics of current, common JEV strains in this region. Research on mosquito species diversity in different habitats in Huaihua revealed that local community composition was relatively simple, including five species from four genera (two\n                    <jats:italic toggle=\"yes\">Culex<\/jats:italic>\n                    spp., one\n                    <jats:italic toggle=\"yes\">Anopheles<\/jats:italic>\n                    sp., one\n                    <jats:italic toggle=\"yes\">Aedes<\/jats:italic>\n                    sp., and one\n                    <jats:italic toggle=\"yes\">Armigeres<\/jats:italic>\n                    sp.).\n                    <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic>\n                    was clearly the dominant species comprising 94.2\u201398.6% of all specimens and was always the most common species captured in paddy fields, pigpens, and human dwellings. The seasonal abundance of\n                    <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic>\n                    was relatively even, with a single seasonal peak in late August. Two Huaihua JEV strains isolated from the mosquito and pig were highly congruent. The genetic affinities were determined by analyzing capsid\/premembrane (C\/PrM) and envelope (E) gene variation. The results showed that they were of genotype III and most closely related to the live, attenuated vaccine strains SAl4-14-2 and SA14 and JaGAr01. The Huaihua E protein shares high similarity (mosquito 98.8% and pig 97.6%) at the nucleotide level with the SA14-14-2 vaccine. Although we found that the E gene sequences of the Huaihua JEV mosquito strain and pig strain have 11 and 15 amino acid site substitutions compared with the SAl4-14-2 vaccine, key sites that associated with JEV's antigenic activity and neurovirulence were unchanged. The SA14-14-2 vaccine should therefore be effective in preventing JEV infection in the Huaihua region.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2019.2453","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T14:53:55Z","timestamp":1560264835000},"page":"933-944","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vector Mosquito Ecology and Japanese Encephalitis Virus Genotype III Strain Detection from\n                    <i>Culex tritaeniorhynchus<\/i>\n                    and Pig in Huaihua, China"],"prefix":"10.1177","volume":"19","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."},{"name":"PLA Rocket Army Characteristic Medical Center, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yande","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-017-0197-9"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3937.1345"},{"key":"e_1_3_4_4_1","first-page":"457","article-title":"Progress in the research of phenotype and genotype of Japanese encephalitis virus in China [in Chinese]","volume":"29","author":"Chen N","year":"2013","unstructured":"Chen N, , Yu YX. 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