{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:54:40Z","timestamp":1777877680656,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    Trichinosis is a worldwide zoonotic disease closely related to cultural and dietary habits caused by a nematode\n                    <jats:italic toggle=\"yes\">Trichinella<\/jats:italic>\n                    spp. The drugs for its prevention and treatment are still not thoroughly defined. Wortmannilactone F was used to value the therapeutic effects on the worm reduction rates, change of the intestinal mucosa, and the host's body's immune activity in this experiment. BALB\/c mice were orally fed with 200 infective\n                    <jats:italic toggle=\"yes\">Trichinella spiralis<\/jats:italic>\n                    larvae. Then,\n                    <jats:italic toggle=\"yes\">T. spiralis<\/jats:italic>\n                    -infected mice were treated with wortmannilactone F (50, 100, and 200\u2009mg\/kg). The number and morphological analysis of adult worm, the expression of Factor associated suicide (Fas), and the level of SIgA in the mice were investigated. Wortmannilactone F showed dose-dependent anthelmintic effects by causing mortality of worms, obvious damaging effects on mature\n                    <jats:italic toggle=\"yes\">T. spiralis<\/jats:italic>\n                    ' surface and their digestive systems, decreasing the expression of mice's intestinal mucosa's Fas protein, and reducing intestinal mucosa's level of SIgA secretions. Wortmannilactone F is expected to be a potential therapeutic drug for trichinellosis treatment.\n                  <\/jats:p>","DOI":"10.1089\/vbz.2019.2482","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T10:45:31Z","timestamp":1573469131000},"page":"205-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Wortmannilactone F on\n                    <i>Trichinella spiralis<\/i>\n                    Enteral in Mice"],"prefix":"10.1177","volume":"20","author":[{"given":"Yuanhua","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Parasitology, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cen","family":"Yi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Wuhan No.1 Hospital, Wuhan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawila","family":"Chileshe","sequence":"additional","affiliation":[{"name":"2017 International Education College, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microorganism Examination, Dalian Center for Disease Control and Prevention, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuesheng","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Dalian Medical University, Dalian, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150295"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(98)00084-9"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00026-08"},{"key":"e_1_3_3_5_1","first-page":"499","article-title":"Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya","volume":"73","author":"Jaoko WG","year":"1996","unstructured":"Jaoko WG, , Muchemi G, , Oguya FO. 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