{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:44:55Z","timestamp":1789771495665,"version":"4.0.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>We previously reported two hamster models for viscerotropic yellow fever virus (YFV) infection: one using a YFV strain (Jim\u00e9nez), isolated from a fatal human case in Panama in 1974, and the other using the prototype YFV strain (Asibi). Asibi hamster passage 7 (P7) was associated with accumulation of seven amino acid substitutions, including five in the envelope protein. In this study we report the genome sequences of the hamster Jim\u00e9nez P0 and P10 viruses in which we identified only two amino acid substitutions during passage, one each in the nonstructural proteins NS3 and NS5, indicating a role for the nonstructural proteins in increased YFV viscerotropism in the Jim\u00e9nez hamster model. Thus, there are multiple molecular mechanisms involved in viscerotropism of YFV in the hamster model. Neither Asibi P7 nor Jim\u00e9nez P10 viruses were viscerotropic in mice or guinea pigs. Thus, the hamster viscerotropic phenotype did not translate to other laboratory rodent species.<\/jats:p>","DOI":"10.1089\/vbz.2019.2495","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T17:57:10Z","timestamp":1575395830000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular Characterization of Hamster-Adapted Yellow Fever Virus"],"prefix":"10.1177","volume":"20","author":[{"given":"Monica A.","family":"McArthur","sequence":"first","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland."},{"name":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliu L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas."},{"name":"Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Tesh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.T.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas."},{"name":"Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104248200"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00588-10"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001910"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.11.6797-6807.1993"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-866"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05186-3"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9213"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191652"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.11.2757"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001033"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(00)00270-6"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005897"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.03.010"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03368-14"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01074-08"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0053-x"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-4-733"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2435-4"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(03)59002-9"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.2.1462-1468.2003"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.01.004"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.030"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.9.5573"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3924"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80977-3"},{"key":"e_1_3_5_27_1","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed LJ","year":"1938","unstructured":"Reed LJ, , Muench H. 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