{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:46:48Z","timestamp":1787726808583,"version":"build-2784847793"},"reference-count":16,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Brucellosis is the most common zoonotic infection worldwide, and is caused by bacterial genus Brucella. The disease is rarely transmitted through human-to-human transmission. Few cases have been reported about vertical transmission of human brucellosis. Herein, we reported a case of congenital brucellosis, with clear evidence of pathogen detected in mother's placental specimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>\n                      A 34-day-old girl was admitted to the department of pulmonology with fever for 8 days. Three blood samples and one sample of cerebrospinal fluid were positive for\n                      <jats:italic toggle=\"yes\">Brucella melitensis<\/jats:italic>\n                      . The diagnosis of brucellosis and\n                      <jats:italic toggle=\"yes\">B. melitensis<\/jats:italic>\n                      meningitis were established, along with hyperbilirubinemia and liver dysfunction. Treatment of rifampicin (for 6 weeks) and meropenem (for 2 weeks) was administered. However, the disease relapsed within 18 days. Thereafter, a combination therapy of rifampicin and sulfamethoxazole\/trimethiprim (SMZ\/TMP) was administered for 8 weeks. The disease relapsed again in 42 days. For chronic brucellosis, three courses of combination therapy of rifampicin and SMZ\/TMP was administered. The mother had fatigue and arthralgia for 2 weeks, fever and membrane rupture 1 day before the baby was born.\n                      <jats:italic toggle=\"yes\">B. melitensis<\/jats:italic>\n                      DNA was detected in the mother's placental specimen by next-generation sequencing and bacterial identification under microscope proved chorioamnionitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We reported a confirmed case of congenital brucellosis. This disease should be closely monitored even in nonepidemic areas. The treatment of brucellosis in infancy faces challenges of drug choice and disease relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2021.0015","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:49:38Z","timestamp":1631893778000},"page":"727-730","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Congenital Brucellosis: A Case Report"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-746X","authenticated-orcid":false,"given":"Dan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, and The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-1678","authenticated-orcid":false,"given":"Yingshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2018.2280"},{"key":"e_1_3_6_3_1","first-page":"757","article-title":"Pulmonary involvement in brucellosis, a rare complication of renal transplant: Case report and brief review","volume":"16","author":"Ay N","year":"2018","unstructured":"Ay N, , Kaya S, , Anil M, et al. Pulmonary involvement in brucellosis, a rare complication of renal transplant: Case report and brief review. Exp Clin Transplant, 2018. 16:757\u2013760.","journal-title":"Exp Clin Transplant"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70286-4"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2002.1043"},{"key":"e_1_3_6_6_1","first-page":"46","article-title":"Human brucellosis: An overview","volume":"6","author":"Hasanjani Roushan MR","year":"2015","unstructured":"Hasanjani Roushan MR, , Ebrahimpour S. Human brucellosis: An overview. Caspian J Intern Med, 2015; 6:46\u201347.","journal-title":"Caspian J Intern Med"},{"key":"e_1_3_6_7_1","article-title":"An outbreak of brucellosis: An adult and pediatric case series","volume":"6","author":"Hassouneh L","year":"2019","unstructured":"Hassouneh L, , Quadri S, , Pichilingue-Reto P, et al. An outbreak of brucellosis: An adult and pediatric case series. Open Forum Infect Dis, 2019; 6:ofz384.","journal-title":"Open Forum Infect Dis"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199305000-00005"},{"key":"e_1_3_6_9_1","first-page":"323","article-title":"Guidelines for diagnosis and treatment of brucellosis (Trial)","volume":"25","author":"Ministry of Health of the People's Republic of China","year":"2012","unstructured":"Ministry of Health of the People's Republic of China. Guidelines for diagnosis and treatment of brucellosis (Trial). Infect Dis Inf, 2012; 25:323\u2013324, 359.","journal-title":"Infect Dis Inf"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520975576"},{"key":"e_1_3_6_11_1","first-page":"1","article-title":"Joint FAO\/WHO expert committee on brucellosis","volume":"740","author":"No Authors","year":"1986","unstructured":"No Authors. Joint FAO\/WHO expert committee on brucellosis. 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Epidemic situation and exploration of the prevention and control strategies on Brucellosis in Zhejiang Province. Chin Rural Health Service Administration, 2007; 27:209\u2013211.","journal-title":"Chin Rural Health Service Administration"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072382"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519838921"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2021.0015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2021.0015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2021.0015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:01:07Z","timestamp":1777590067000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2021.0015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1089\/vbz.2021.0015"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2021.0015","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}