{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:19:11Z","timestamp":1791001151028,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Lyme borreliosis (LB) is a growing public health concern requiring accurate and comprehensive epidemiological knowledge to inform health care interventions. This study compared the epidemiology of LB in primary care and hospital settings, using for the first time in France three sources of data, and highlighted specific populations at higher risk of developing LB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study analyzed data from general practitioner networks (\n                      <jats:italic toggle=\"yes\">i.e<\/jats:italic>\n                      ., Sentinel network, Electronic Medical Records [EMR]) and the national hospital discharge database to describe the LB epidemiology from 2010 to 2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The average annual incidence rates of LB in primary care increased from 42.3 cases\/100,000 population in 2010\u20132012 to 83.0\/100,000 in 2017\u20132019 for the Sentinel Network and 42.7\/100,000 to 74.6\/100,000 for the EMR, following a marked rise in 2016. The annual hospitalization rate remained stable from 2012 to 2019 fluctuating between 1.6 and 1.8 hospitalizations\/100,000. Women were more likely to present with LB in primary care setting compared with men (male-to-female incidence rate ratio [IRR]\u2009=\u20090.92), whereas men were predominant among hospitalizations (IRR\u2009=\u20091.4), with the largest discordance among adolescents aged 10\u201314 years (IRR\u2009=\u20091.8) and adults aged 80 years and older (IRR\u2009=\u20092.5). In 2017\u20132019, the average annual incidence rate peaked among persons aged 60\u201369 years in primary care (&gt;125\/100,000) and aged 70\u201379 years among hospitalized patients (3.4\/100,000). A second peak occurred in children aged 0\u20134 or 5\u20139 years depending on sources. Incidence rates in Limousin and the north-eastern regions were the highest for both primary care and hospital settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Analyses showed disparities in the evolution of incidence, sex-specific incidence rates, and predominant age groups between primary care and hospital settings that merit further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2022.0050","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T11:44:14Z","timestamp":1681818254000},"page":"221-229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Epidemiology of Lyme Borreliosis in France in Primary Care and Hospital Settings, 2010\u20132019"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-8023","authenticated-orcid":false,"given":"Charles","family":"Nuttens","sequence":"first","affiliation":[{"name":"Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer SAS, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bessou","sequence":"additional","affiliation":[{"name":"IQVIA Op\u00e9rations France, Courbevoie, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Duret","sequence":"additional","affiliation":[{"name":"IQVIA Op\u00e9rations France, Courbevoie, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-5046","authenticated-orcid":false,"given":"Jozica","family":"Skufca","sequence":"additional","affiliation":[{"name":"Pharmacovigilance and Epidemiology Services, P95, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Blanc","sequence":"additional","affiliation":[{"name":"Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer SAS, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-3845","authenticated-orcid":false,"given":"Andreas","family":"Pilz","sequence":"additional","affiliation":[{"name":"Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer Corporation Austria, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-7194","authenticated-orcid":false,"given":"Bradford D.","family":"Gessner","sequence":"additional","affiliation":[{"name":"Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer, Inc., Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Faucher","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales, CHU de Limoges, Limoges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-876X","authenticated-orcid":false,"given":"James H.","family":"Stark","sequence":"additional","affiliation":[{"name":"Vaccine Medical Development, Scientific and Clinical Affairs, Pfizer, Inc., Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1539-2"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0659-1"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2018.02.011"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210383082"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206071639"},{"key":"e_1_3_6_7_1","unstructured":"Google. Google Trends for \u201cLyme.\u201d 2022. Available from: https:\/\/trends.google.fr\/trends\/explore?date=all&geo=FR&q=Lyme [Last accessed: November 17 2022]."},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02360.x"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-02144-2"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1041"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2017.03.013"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.77240"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.10.006"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckz198"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2011.04.002"},{"key":"e_1_3_6_16_1","unstructured":"Sant\u00e9 Publique France. Borr\u00e9liose de lyme. 2022. Available from: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-a-transmission-vectorielle\/borreliose-de-lyme\/donnees\/#tabs [Last accessed: December 2 2022]."},{"key":"e_1_3_6_17_1","unstructured":"Sentinelles R. Bilan Annuel 2019. INSERM; 2019. Available from: https:\/\/www.sentiweb.fr\/document\/5017 [Last accessed: May 16 2022]."},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11850-1"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.11.1800134"},{"key":"e_1_3_6_20_1","first-page":"406","article-title":"Incidence of Lyme borreliosis in the alsace districts: Alsa(ce)tique study 2014\u20132015 (in French)","volume":"19","author":"Sophie Raguet YLS","year":"2018","unstructured":"Sophie Raguet YLS, , Chouin L, , Hansmann Y, et al. Incidence of Lyme borreliosis in the alsace districts: Alsa(ce)tique study 2014\u20132015 (in French). 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Lyme borreliosis hospitalized in a university hospital: a retrospective descriptive study. 39th Interdisciplinary Meeting of Anti-Infectious Chemotherapy (RICAI) (in French). Paris 2018."}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2022.0050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2022.0050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2022.0050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:02:08Z","timestamp":1777590128000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2022.0050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1089\/vbz.2022.0050"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2022.0050","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}