{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:56:41Z","timestamp":1777877801021,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Leptospirosis is a bacterial zoonosis of worldwide distribution with a wide spectrum of clinical presentations that range from subclinical or mild to severe and fatal outcomes. Identifying clinical predictors for the severe form of the disease is critical to reduce disease complications and death. As a result, we conducted a retrospective case\u2013control study to identify clinical markers of mortality in leptospirosis patients from the Transcarpathian region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study used 102 medical records of patients with leptospirosis in the period from 2009 to 2019. There were 26 fatal cases and 76 survivors. Predictors were examined using univariate and bivariate statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fatal and nonfatal groups did not differ in age or gender composition (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.5), nor did they differ in signs or symptoms, except that oliguria occurred significantly more often in fatal cases (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Laboratory diagnostic tests, however, differed between outcomes in 7\/9 recorded variables; primarily associated with liver and kidney function as well thrombocytopenia and elevated white blood cell counts for fatal cases (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all variables).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Logistic regression analysis indicated that a combination of creatinine levels and direct bilirubin levels were the best predictors of patient outcome. The specificity of the model was 90.9% and the area under the receiver operator characteristic function as 93.6%. This model can be used when a patient is admitted to a hospital to better characterize patient risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2022.0063","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T09:23:30Z","timestamp":1669713810000},"page":"584-588","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Leptospirosis: Prognostic Model for Patient Mortality in the Transcarpathian Region, Ukraine"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-4445","authenticated-orcid":false,"given":"Pavlo","family":"Petakh","sequence":"first","affiliation":[{"name":"Department of Microbiology, Virology and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine."},{"name":"Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliia","family":"Isevych","sequence":"additional","affiliation":[{"name":"Uzhhorod National University, Uzhhorod, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issah Bin","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Uzhhorod National University, Uzhhorod, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-4539","authenticated-orcid":false,"given":"Andriy","family":"Nykyforuk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larysa","family":"Rostoka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.03.012"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00830-2"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-835678"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702008000300016"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i35.5553"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003898"},{"issue":"1","key":"e_1_3_5_8_1","first-page":"1","article-title":"Risk factors for intensive care unit admission in patients with severe leptospirosis: A comparative study according to patients' severity","volume":"16","author":"Daher EDF","year":"2015","unstructured":"Daher EDF, , Soares DS, , de Menezes Fernandes ATB, et al. Risk factors for intensive care unit admission in patients with severe leptospirosis: A comparative study according to patients' severity. BMC Infect Dis, 2015; 16(1):1\u20137.","journal-title":"BMC Infect Dis"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(02)06"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210571"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/513767"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-200037154"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1403.071064"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1602.090139"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2112.141099"},{"issue":"3","key":"e_1_3_5_16_1","first-page":"84","article-title":"Epidemiological features of leptospirosis in Ukraine in the present","volume":"4","author":"Hopko N","year":"2017","unstructured":"Hopko N. Epidemiological features of leptospirosis in Ukraine in the present. Visnyk problem biolohii i medytsyny, 2017; 4(3):84\u201386.","journal-title":"Visnyk problem biolohii i medytsyny"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2018.2356"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202062014"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0776-y"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(02)90137-2"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06766-5"},{"issue":"2","key":"e_1_3_5_22_1","first-page":"79","article-title":"The predictive factors for severe leptospirosis cases in kedah","volume":"5","author":"Sandhu RS","year":"2020","unstructured":"Sandhu RS, , Ismail HB, , Ja'afar MHB, et al. The predictive factors for severe leptospirosis cases in kedah. 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