{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:52:46Z","timestamp":1790646766984,"version":"4.1.0"},"reference-count":81,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lyme borreliosis (LB) is the most common tick-borne disease in Europe, but the burden of disease is incompletely described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a systematic review across PubMed, EMBASE, and CABI Direct (Global Health) databases, from January 1, 2005, to November 20, 2020, of epidemiological studies reporting incidence of LB in Europe (PROSPERO, CRD42021236906).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The systematic review yielded 61 unique articles describing LB incidence (national or subnational) in 25 European countries. Substantial heterogeneity in study designs, populations sampled, and case definitions restricted data comparability. The European Union Concerted Action on Lyme Borreliosis (EUCALB)\u2013published standardized LB case definitions were used by only 13 (21%) of the 61 articles. There were 33 studies that provided national-level LB incidence estimates for 20 countries. Subnational LB incidence was available from an additional four countries (Italy, Lithuania, Norway, and Spain). The highest LB incidences (&gt;100 cases per 100,000 population per year [PPY]) were reported in Belgium, Finland, the Netherlands, and Switzerland. Incidences were 20\u201340\/100,000 PPY in the Czech Republic, Germany, Poland, and Scotland and &lt;20\/100,000 PPY in Belarus, Croatia, Denmark, France, Ireland, Portugal, Russia, Slovakia, Sweden, and the United Kingdom (England, Northern Ireland, and Wales); markedly higher incidences were observed at the subnational level (up to 464\/100,000 PPY in specific local areas).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although countries in Northern (Finland) and Western (Belgium, the Netherlands, and Switzerland) Europe reported the highest LB incidences, high incidences also were reported in some Eastern European countries. There was substantial subnational variation in incidence, including high incidences in some areas of countries with low overall incidence. This review, complemented by the incidence surveillance article, provides a comprehensive view into LB disease burden across Europe that may guide future preventive and therapeutic strategies\u2014including new strategies on the horizon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2022.0070","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T11:44:14Z","timestamp":1681818254000},"page":"172-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["Incidence of Lyme Borreliosis in Europe: A Systematic Review (2005\u20132020)"],"prefix":"10.1177","volume":"23","author":[{"given":"Leah","family":"Burn","sequence":"first","affiliation":[{"name":"P95 Pharmacovigilance and Epidemiology, Princeton, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Vyse","sequence":"additional","affiliation":[{"name":"Pfizer Vaccines Medical, Walton Oaks, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pilz","sequence":"additional","affiliation":[{"name":"Pfizer Global Medical Affairs, Vaccines, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao Mai Phuong","family":"Tran","sequence":"additional","affiliation":[{"name":"P95 Pharmacovigilance and Epidemiology, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Pfizer Emerging Markets Medical Affairs, Vaccines, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J.","family":"Angulo","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc., Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford D.","family":"Gessner","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc., Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Mo\u00efsi","sequence":"additional","affiliation":[{"name":"Pfizer Medical Development, Scientific and Clinical Affairs, Vaccines, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-876X","authenticated-orcid":false,"given":"James H.","family":"Stark","sequence":"additional","affiliation":[{"name":"Vaccines Medical Development, Scientific and Clinical Affairs, Pfizer, Inc., Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.2564\/6\/654"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2013.13725"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-79"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12885"},{"key":"e_1_3_6_6_1","first-page":"3","article-title":"Lyme borreliosis\u2014Epidemiological analysis of incidence in the northern region of Slovakia","volume":"61","author":"Bochni\u010dkov\u00e1 M","year":"2012","unstructured":"Bochni\u010dkov\u00e1 M, , Szil\u00e1gyiov\u00e1 M, , Gardl\u00edk R. 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