{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:56:57Z","timestamp":1777877817542,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic>\n                      spp. are a type of protozoan parasite responsible for causing diarrheal illness worldwide. They infect a broad range of vertebrate hosts, including both non-human primates (NHPs) and humans. In fact, zoonotic transmission of\n                      <jats:italic toggle=\"yes\">cryptosporidiosis<\/jats:italic>\n                      from NHPs to humans is frequently facilitated by direct contact between the two groups. However, there is a need to enhance the information available on the subtyping of\n                      <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic>\n                      spp. in NHPs in the Yunnan province of China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Thus, the study investigated the molecular prevalence and species of\n                      <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic>\n                      spp. from 392 stool samples of\n                      <jats:italic toggle=\"yes\">Macaca fascicularis<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009335) and\n                      <jats:italic toggle=\"yes\">Macaca mulatta<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200957) by using nested PCR targeting the large subunit of nuclear ribosomal RNA (\n                      <jats:italic toggle=\"yes\">LSU<\/jats:italic>\n                      ) gene. Of the 392 samples, 42 (10.71%) were tested\n                      <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic>\n                      -positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All the samples were identified as\n                      <jats:italic toggle=\"yes\">Cryptosporidium hominis<\/jats:italic>\n                      . Further, the statistical analysis revealed that age is a risk factor for the infection of\n                      <jats:italic toggle=\"yes\">C. hominis.<\/jats:italic>\n                      The probability of detecting\n                      <jats:italic toggle=\"yes\">C. hominis<\/jats:italic>\n                      was found to be higher (odds ratio\u2009=\u20096.23, 95% confidence interval 1.73\u201322.38) in NHPs aged between 2 and 3 years, as compared with those younger than 2 years. Sequence analysis of the 60\u2009kDa glycoprotein (\n                      <jats:italic toggle=\"yes\">gp60<\/jats:italic>\n                      ) identified six (IbA9\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094, IiA17\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20095, InA23\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091, InA24\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092, InA25\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093, and InA26\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200918)\n                      <jats:italic toggle=\"yes\">C. hominis<\/jats:italic>\n                      subtypes with \u201cTCA\u201d repeats. Among these subtypes, it has been previously reported that the Ib family subtypes are also capable of infecting humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The findings of this study highlight the genetic diversity of\n                      <jats:italic toggle=\"yes\">C. hominis<\/jats:italic>\n                      infection among\n                      <jats:italic toggle=\"yes\">M. fascicularis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">M. mulatta<\/jats:italic>\n                      in Yunnan province. Further, the results confirm that both these NHPs are susceptible to\n                      <jats:italic toggle=\"yes\">C. hominis<\/jats:italic>\n                      infection, posing a potential threat to humans.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2023.0008","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:32:01Z","timestamp":1686915121000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Subtyping of Nonhuman Primate-Adapted\n                    <i>Cryptosporidium hominis<\/i>\n                    in\n                    <i>Macaca Fascicularis<\/i>\n                    and\n                    <i>Macaca mulatta<\/i>\n                    in Yunnan Province, Southwestern China"],"prefix":"10.1177","volume":"23","author":[{"given":"Yue-Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Veterinary Public Health, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, P.R. China."},{"name":"State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Veterinary Public Health, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Ping","family":"Ma","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University, Changsha, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China."},{"name":"Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Veterinary Public Health, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, P.R. 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