{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:57:40Z","timestamp":1790625460938,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus and the leading cause of pediatric encephalitis in the Asian Pacific region. The transmission cycle primarily involves\n                      <jats:italic toggle=\"yes\">Culex<\/jats:italic>\n                      spp. mosquitoes and Ardeid birds, with domestic pigs (\n                      <jats:italic toggle=\"yes\">Sus scrofa domestica<\/jats:italic>\n                      ) being the source of infectious viruses for the spillover of JEV from the natural endemic transmission cycle into the human population. Although many studies have concluded that domestic pigs play an important role in the transmission cycle of JEV, and infection of humans, the role of feral pigs in the transmission of JEV remains unclear. Since domestic and feral pigs are the same species, and because feral pig populations in the United States are increasing and expanding geographically, the current study aimed to test the hypothesis that if JEV were introduced into the United States, feral pigs might play a role in the transmission cycle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Sinclair miniature pigs, that exhibit the feral phenotype, were intradermally inoculated with JEV genotype Ib. These pigs were derived from crossing miniature domestic pig with four strains of feral pigs and were used since obtaining feral swine was not possible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The Sinclair miniature pigs became viremic and displayed pathological outcomes similar to those observed in domestic swine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on these findings, we conclude that in the event of JEV being introduced into the United States, feral pig populations could contribute to establishment and maintenance of a transmission cycle of JEV and could lead to the virus becoming endemic in the United States.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2023.0030","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:13:12Z","timestamp":1694009592000},"page":"645-652","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Infection of Feral Phenotype Swine with Japanese Encephalitis Virus"],"prefix":"10.1177","volume":"23","author":[{"given":"So Lee","family":"Park","sequence":"first","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA."},{"name":"Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jang S.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA."},{"name":"Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA."},{"name":"Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria B.","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA."},{"name":"Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Hettenbach","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA."},{"name":"Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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