{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:38:48Z","timestamp":1781761128068,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tularemia is one of the most prevalent zoonoses across the world. Patients in Turkiye mostly contract the oropharyngeal form, acquired through drinking, or contact with microorganism-contaminated water.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with oropharyngeal tularemia aged under 18 years and diagnosed between January 01, 2017, and December 31, 2020, were evaluated retrospectively. Tularemia was diagnosed in patients with compatible histories, symptoms, clinical presentations, and laboratory test results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of 38 children was 12.1 \u00b1 3.4 years, and the female\/male ratio was 0.58 (14\/24). The mean duration of symptoms on admission was 33.8 \u00b1 26.2 days. All children had enlarged lymph nodes. Malaise, fever, and loss of appetite were other frequent symptoms. Patients were treated with antibiotics for a mean of 26.2 \u00b1 18.8 days. Gentamycin was the most frequently used antibiotic (either alone or in combination) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 29, 76.3%). Twenty-six (68.4%) patients underwent surgical procedures in addition to antibiotherapy. Five (13.2%) required secondary total excision. Patients with higher leukocyte counts at admission received a combination of antibiotherapy plus surgery, rather than antibiotics alone. No relapses, reretreatment requirement, or mortality were observed after 12 months of follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Oropharyngeal tularemia in children can require longer courses of antibiotic treatment with more than one drug and more frequent surgery than previously suggested in the literature, especially if the patients are admitted late to the hospital, symptom duration is prolonged, and appropriate treatment is initiated late. Higher leukocyte counts on admission may be prognostic for longer antibiotic treatment course and suppurative complications that require surgery. Raising awareness among patients and physicians is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2023.0076","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T06:28:55Z","timestamp":1713853735000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric Oropharyngeal Tularemia Cases: Challenges in Management"],"prefix":"10.1177","volume":"24","author":[{"given":"Soner Sertan","family":"Kara","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Aydin Adnan Menderes University, Aydin, Turkiye."},{"name":"Department of Pediatric Infectious Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Turkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Turkiye."},{"name":"Department of Pediatric Infectious Diseases, Gazi University, Ankara, Turkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Hafize","family":"Erdeniz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Turkiye."},{"name":"Department of Pediatric Infectious Diseases, Samsun Ondokuz Mayis University, Samsun, Turkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Sena","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Erzurum Regional Training and Research Hospital, Erzurum, Turkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_3_4_2_1","first-page":"822","volume-title":"Red Book: 2021 Report of the Committee on Infectious Diseases","author":"American Academy of Pediatrics","year":"2021","unstructured":"American Academy of Pediatrics. Tularemia. In: Red Book: 2021 Report of the Committee on Infectious Diseases, 32nd ed, (Kimberlin DW, , Barnett ED, , Lynfield R, , Sawyer MH. eds), American Academy of Pediatrics: Itasca, IL, 2021; pp. 822\u2013825.","edition":"32"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.67.295"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1638734"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002932"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-022-01837-4"},{"issue":"2","key":"e_1_3_4_7_1","first-page":"105","article-title":"Tularemia in children: Evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases","volume":"54","author":"Kaya A","year":"2012","unstructured":"Kaya A, , Deveci K, , Uysal IO, et al. Tularemia in children: Evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases. Turk J Pediatr, 2012; 54(2):105\u2013112.","journal-title":"Turk J Pediatr"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12552"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.986463"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2013.1517"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.5152\/ced.2012.28"},{"issue":"1","key":"e_1_3_4_12_1","first-page":"108","article-title":"[Evaluation of epidemiologic and clinical features of oropharyngeal tularemia patients in the Eastern Anatolia Region of Turkiye]","volume":"52","author":"\u00d6zden K","year":"2018","unstructured":"\u00d6zden K, , \u00d6zden A, , Albayrak A, et al. [Evaluation of epidemiologic and clinical features of oropharyngeal tularemia patients in the Eastern Anatolia Region of Turkiye]. Mikrobiyol Bul, 2018; 52(1):108\u2013110.","journal-title":"Mikrobiyol Bul"},{"key":"e_1_3_4_13_1","doi-asserted-by":"crossref","unstructured":"Penn RL. Tularemia: Clinical manifestations diagnosis treatment and prevention. 2023. Available from: https:\/\/www.uptodate.com\/contents\/tularemia-clinical-manifestations-diagnosis-treatment-and-prevention?search=tularemi&source=search_result&selectedTitle=1\u223c65&usage_type=default&display_rank=1#H3907701311 [Last accessed: March13 2023].","DOI":"10.33029\/9704-7866-0-CCYX-2023-1-216"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2906.221395"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01104-12"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.14886"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac292"},{"issue":"2","key":"e_1_3_4_18_1","first-page":"305","article-title":"Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons","volume":"47","author":"Shahsavari S","year":"2018","unstructured":"Shahsavari S, , Baghi HB, , Kafil HS, et al. Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons? Iran J Public Health, 2018; 47(2):305\u2013306.","journal-title":"Iran J Public Health"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2101.131127"},{"key":"e_1_3_4_20_1","unstructured":"Turkish Ministry of Health. Zoonotic and Vectorial Diseases Department. Tularemia statistical data. Available from: https:\/\/hsgm.saglik.gov.tr\/tr\/zoonotikvektorel-tularemi\/istatistik [Last accessed: April23 2023]."},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis706"},{"key":"e_1_3_4_22_1","unstructured":"World Health Organization. WHO Guidelines on Tularaemia. 2007. Available from: https:\/\/stacks.cdc.gov\/view\/cdc\/6943 [Last accessed: October23 2023]."}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2023.0076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2023.0076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2023.0076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:03:14Z","timestamp":1777590194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2023.0076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1089\/vbz.2023.0076"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2023.0076","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}