{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:31:59Z","timestamp":1790710319851,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tick-borne encephalitis (TBE) is caused by the tick-borne encephalitis virus (TBEV). TBEV infection can cause symptoms of central nervous system (CNS) inflammation and result in severe consequences including death. TBE is an increasing health threat in the Czech Republic and elsewhere in Europe. In 2020, 23% of 3734 TBE cases reported to the European Centre for Disease Prevention and Control were from the Czech Republic. TBE vaccination is universally recommended in the Czech Republic, but a full analysis of TBE vaccine effectiveness (VE) in the Czech Republic has not been published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      TBE is a notifiable disease in the Czech Republic with mandatory reporting of cases (\n                      <jats:italic toggle=\"yes\">i.e.,<\/jats:italic>\n                      laboratory-confirmed TBEV infected patient with symptoms of CNS inflammation) and vaccination history to public health authorities. TBE VE was estimated using the screening method utilizing public health surveillance data from 2018 to 2022 and online household surveys of the general population on TBE vaccine uptake conducted in 2019\u22122022.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 2018\u22122022, 3648 TBE cases were reported in the Czech Republic; 98.1% (3105\/3166) of TBE cases with known vaccination history were unvaccinated. Among 42,671 persons surveyed from the general population who had known TBE vaccination history, 66.5% were unvaccinated. VE against TBE was 97.6% (95% confidence interval 95.7\u221298.7). When stratified by age group, VE was 97.1% (88.4\u221299.3) in 1\u221215 years of age, 97.9% (95.3\u221299.0) in 16\u221259 years of age, and 96.9% (90.5\u221299.0) in \u226560 years of age. TBE vaccination averted an estimated 1020 TBE cases in the Czech Republic from 2018 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This first published study with a full analysis of TBE VE in the Czech Republic showed that vaccination was highly effective for the prevention of TBE including in children, an age group with increasing TBE disease burden. Vaccination averted hundreds of TBE cases and hospitalizations despite the relatively low compliance with TBE vaccine recommendations. To prevent additional TBE cases in the Czech Republic, enhanced efforts to increase TBE vaccine uptake are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2023.0166","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T05:16:45Z","timestamp":1719811005000},"page":"607-613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Vaccination Against Tick-Borne Encephalitis in the Czech Republic, 2018\u22122022"],"prefix":"10.1177","volume":"24","author":[{"given":"Jan","family":"Kyncl","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Epidemiology, Centre for Epidemiology and Microbiology, National Institute of Public Health, Prague, Czech Republic."},{"name":"Department of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J.","family":"Angulo","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Orlikova","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Epidemiology, Centre for Epidemiology and Microbiology, National Institute of Public Health, Prague, Czech Republic."},{"name":"Department of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Vlckova","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, National Institute of Public Health, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Maly","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, National Institute of Public Health, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Krivohlavkova","sequence":"additional","affiliation":[{"name":"Pfizer Biopharmaceuticals Group, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Harper","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita","family":"Edwards","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Bender","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pilz","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Erber","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Madhava","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, London, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Mo\u00efsi","sequence":"additional","affiliation":[{"name":"Vaccines, Antivirals, and Evidence Generation, Pfizer Vaccines, Pfizer Inc, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_3_5_2_1","unstructured":"Czech Republic Parliament. Act No 258\/2000 Coll. on the protection of public health and amending certain related acts. Z\u00e1kon \u010d. 258\/2000 Sb. o ochran\u011b ve\u0159ejn\u00e9ho zdrav\u00ed a o zm\u011bn\u011b souvisej\u00edc\u00edch p\u0159edpis\u016f. (in Czech). 2000. Available from: https:\/\/www.sbirka.cz\/POSL4TYD\/NOVE\/23\u2032167.htm [Last accessed December20 2023]."},{"key":"e_1_3_5_3_1","unstructured":"Czech Vaccination Society of the Czech Medical Association of J. E. Purkyn\u011b. 2016. Recommended procedure of the Czech Vaccination Society for prevention and vaccination against tick-borne encephalitis (in Czech). Available from: https:\/\/www.vakcinace.eu\/data\/files\/doporuceniprokevakcinaci_2016final_schvaleno_vyborem.pdf [Last accessed: December20 2023]."},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.12.028"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2018.02.007"},{"key":"e_1_3_5_6_1","unstructured":"European Centre for Disease Prevention and Control (ECDC). European Union surveillance case definitions as published in the Official Journal of the European Union (Commission Implementing Decision (EU) 2018\/945). 2018. Available from: https:\/\/ecdc.europa.eu\/en\/surveillance-and-disease-data\/eu-case-definitions [Last accessed: December20 2023]."},{"key":"e_1_3_5_7_1","unstructured":"European Centre for Disease Prevention and Control (ECDC). Tick-borne encephalitis Annual Epidemiological Report for. 2015. Available from: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/AER_for_2015-tick-borne-encephalitis.pdf [Last accessed: December20 2023]."},{"key":"e_1_3_5_8_1","unstructured":"European Centre for Disease Prevention and Control (ECDC). Tick-borne encephalitis Annual Epidemiological Report for 2020. Available from: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/tick-borne-encephalitis-annual-epidemiological-report-2020 [Last accessed: December20 2023]."},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/22.4.742"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0900"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0264-410x(02)00813-7"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071283"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)60800-4"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15447-5"},{"key":"e_1_3_5_15_1","volume-title":"24th International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE) Meeting","author":"Orlikova H","year":"2022","unstructured":"Orlikova H, , Kyncl J. Epidemiology of tick-borne encephalitis (TBE) in the Czech Republic, trends and current situation. Presented at: 24th International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE) Meeting. Vienna, Austria; 2022."},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2022.102059"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.01.004"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac075"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2021.101779"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2010.10.007"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.07.024"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-061228"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2023.0166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2023.0166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2023.0166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:03:48Z","timestamp":1777590228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2023.0166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1089\/vbz.2023.0166"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2023.0166","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}