{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:02:42Z","timestamp":1784016162215,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lyme borreliosis (LB) remains a public health concern in France despite improved patient management and medical care. Stay-at-home restrictions during the COVID-19 pandemic, which affected participation in outdoor recreational activities and disrupted access to health care services, may have impacted the risk of developing LB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed data from two general practitioner networks in France (Sentinel Network and an electronic medical records database [EMR]) and the national hospital discharge database to describe LB epidemiology in 2020\u20132021 and compare it to previous years. Google Trends\u2019 search volume was used to evaluate the association between the population\u2019s interest in LB and the evolving epidemiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Annual LB incidence rates in primary care decreased from 104 cases\/100,000 population in 2018 to 71\/100,000 in 2021 and from 82\/100,000 to 60\/100,000 according to Sentinel Network and EMR, respectively. Google Trends\u2019 search volume for \u201cLyme\u201d followed a similar trend, one year earlier. Annual hospitalizations were stable from 2012\u20132019 (1.6\/100,000 on average) and declined to 1.3\/100,000 in 2020 and 1.1\/100,000 in 2021. This decline was observed primarily in adults (\n                      <jats:italic toggle=\"yes\">e.g.,<\/jats:italic>\n                      3.4\/100,000 in 2017\u20132019 to 1.8\/100,000 in 2020\u20132021 for 70\u201379 years of age). Changes in regional incidence rates in primary care from 2017\u20132019 to 2020\u20132021 ranged from \u221275% to 208%. Hospitalizations decreased in all regions except in Bretagne.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The estimated LB incidence decreased in 2020 and 2021 compared with previous years but this change may not be related to COVID-19. The incidence decrease observed in primary care could result from reduced population interest in LB, leading to lower care-seeking behavior. The decrease in LB hospitalizations may be explained by changes in clinical practice. Surveillance systems are critical to understand the evolution of LB epidemiology. However, external factors impacting incidence estimates should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2024.0006","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T14:12:25Z","timestamp":1721139145000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Evolution of Lyme Borreliosis Epidemiology in Primary Care and Hospital Settings in France During the COVID-19 Pandemic"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-8023","authenticated-orcid":false,"given":"Charles","family":"Nuttens","sequence":"first","affiliation":[{"name":"Vaccines\/Antivirals &amp; Evidence Generation, Pfizer PIO, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Duret","sequence":"additional","affiliation":[{"name":"IQVIA Op\u00e9rations France, Courbevoie, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bessou","sequence":"additional","affiliation":[{"name":"IQVIA Op\u00e9rations France, Courbevoie, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-7751","authenticated-orcid":false,"given":"Elisabeth","family":"Baux","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales, Centre de R\u00e9f\u00e9rence des Maladies Vectorielles \u00e0 Tiques, R\u00e9gion Est, CHU de Nancy, Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Faucher","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales, CHU de Limoges, Limoges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-3845","authenticated-orcid":false,"given":"Andreas","family":"Pilz","sequence":"additional","affiliation":[{"name":"Vaccines\/Antivirals &amp; Evidence Generation, Pfizer Corporation Austria GmbH, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-5630","authenticated-orcid":false,"given":"Jennifer C.","family":"Mo\u00efsi","sequence":"additional","affiliation":[{"name":"Vaccines\/Antivirals &amp; Evidence Generation, Pfizer PIO, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-876X","authenticated-orcid":false,"given":"James H.","family":"Stark","sequence":"additional","affiliation":[{"name":"Vaccines\/Antivirals &amp; Evidence Generation, Pfizer Inc, Collegeville, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_3_7_2_1","unstructured":"Agence technique de l\u2019information sur l\u2019hospitalisation (ATIH). National hospital discharge data from Programme de M\u00e9dicalisation des Syst\u00e8mes d\u2019Information (PMSI). 2021. Available from: http:\/\/www.atih.sante.fr [Last accessed: April19 2023]."},{"key":"e_1_3_7_3_1","unstructured":"Agence technique de l\u2019information sur l\u2019hospitalisation (ATIH). Statistics on national hospital discharge data from Programme de M\u00e9dicalisation des Syst\u00e8mes d\u2019Information (PMSI). 2023. Available from: https:\/\/www.scansante.fr\/ [Last accessed: December1 2023]."},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0071"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210383082"},{"key":"e_1_3_7_6_1","unstructured":"Eddelbuette D Massicotte P. Package \u2018gtrendsR\u2019. Version 1.5.1. 2022."},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2019.04.381"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2019.05.001"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70119-4"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0067"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0050"},{"key":"e_1_3_7_12_1","unstructured":"R\u00e9seau Sentinelles. Lyme Disease. 2021. Available from: https:\/\/www.sentiweb.fr\/france\/fr\/?page=maladies&mal=18 [Last accessed: April19 2023]."},{"key":"e_1_3_7_13_1","unstructured":"R\u00e9seau Sentinelles. Results of annual Lyme borreliosis surveillance (January-December 2022). 2022. Available from: https:\/\/www.sentiweb.fr\/document\/6012 [Last accessed: December1 2023]."},{"key":"e_1_3_7_14_1","unstructured":"Sant\u00e9 publique France. Borr\u00e9liose de Lyme: Donn\u00e9es. Surveillance nationale de la borr\u00e9liose de Lyme [in French]. 2022 Available from: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-a-transmission-vectorielle\/borreliose-de-lyme\/donnees\/#tabs [Last accessed: April23 2024]."},{"key":"e_1_3_7_15_1","unstructured":"Sant\u00e9 publique France. Cases of tick-borne encephalitis (TBE) declared in France from May 2021 to May 2023. 2023. Available from: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-a-transmission-vectorielle\/encephalite-a-tiques\/documents\/bulletin-national\/encephalites-a-tiques-tbe-en-france.-bilan-des-cas-declares-de-mai-2021-a-mai-2023#:\u223c:text=71%20cas%20ont%20%C3%A9t%C3%A9%20notifi%C3%A9s leur%20lieu%20habituel%20de%20r%C3%A9sidence [Last accessed: December1 2023]."},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11850-1"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.Es.2019.24.11.1800134"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60103-7"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx534"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.es2014.19.34.20883"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030803"}],"container-title":["Vector-Borne and Zoonotic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vbz.2024.0006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2024.0006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vbz.2024.0006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:03:57Z","timestamp":1777590237000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vbz.2024.0006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1089\/vbz.2024.0006"],"URL":"https:\/\/doi.org\/10.1089\/vbz.2024.0006","relation":{},"ISSN":["1530-3667","1557-7759"],"issn-type":[{"value":"1530-3667","type":"print"},{"value":"1557-7759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}