{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:57:43Z","timestamp":1777877863168,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dengue virus (DENV) infection, caused by serotypes DENV 1\u20134, represents a significant global public health challenge, with no antiviral drugs currently available for treatment. The host Protein kinase B (AKT) signaling pathway is crucial for DENV infection, presenting a potential target for antiviral drug development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the antiviral activity of kinase inhibitors that target the AKT pathway, focusing on the compound AT13148. Methods: A mini-screening was conducted to identify kinase inhibitors with antiviral properties against DENV-2. The effects of AT13148 on viral RNA replication and translation were assessed in a dose- and time-dependent manner following DENV-2 entry. The mechanism of action was further investigated by evaluating the impact of AT13148 on AKT kinase activity and phosphorylation status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>AT13148 exhibited potent antiviral activity against DENV-2, significantly inhibiting viral RNA replication and translation post-entry. The compound was found to inhibit AKT kinase activity through hyperphosphorylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings indicate that AT13148 effectively targets the AKT pathway, demonstrating potential as an antiviral therapeutic against DENV-2 by interfering with the virus's post-entry processes. Further in vivo studies are warranted to assess the efficacy of AT13148 in controlling DENV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/vbz.2024.0069","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:18:31Z","timestamp":1736309911000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Compound AT13148 Targeting AKT Suppresses Dengue Virus 2 Replication"],"prefix":"10.1177","volume":"25","author":[{"given":"Yangchao","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuantao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Aerospace Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfeng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi\u2019an, 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