{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:00:29Z","timestamp":1777878029601,"version":"3.51.4"},"reference-count":67,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1089\/vim.2008.0052","type":"journal-article","created":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T14:54:13Z","timestamp":1230648853000},"page":"451-458","source":"Crossref","is-referenced-by-count":10,"title":["CpG Used as an Adjuvant for an Adenovirus-Based Venezuelan Equine Encephalitis Virus Vaccine Increases the Immune Response to the Vector, But Not to the Transgene Product"],"prefix":"10.1177","volume":"21","author":[{"given":"Stuart D.","family":"Perkins","sequence":"first","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn M.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Laws","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Phillpotts","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.048629"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8729-8735.2003"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6290"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4512"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1233578100"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6336"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00123-7"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.6115"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.11.6305-6313.2003"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-004-6244-3"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.01.058"},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636181"},{"key":"p_30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4269\/ajtmh.1965.14.475","volume":"14","author":"de Mucha-Macias J","year":"1965","journal-title":"Am J Trop Med Hyg"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1979.28.329"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10086"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb01013.x"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.07.056"},{"key":"p_35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1152\/ajplegacy.1947.150.1.70","volume":"150","author":"Guyton AC","year":"1947","journal-title":"Am J Physiol"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.095"},{"key":"p_37","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00045-8"},{"key":"p_38","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00042-6"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00042-6"},{"key":"p_40","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00337-1"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.235"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.08.010"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00300-6"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1400"},{"key":"p_45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4531"},{"key":"p_46","first-page":"79","volume":"18","author":"Johnson KM","year":"1974","journal-title":"Adv Vet Sci Comp Med"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00275-7"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200721060-00006"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22873"},{"key":"p_50","first-page":"395","volume":"1","author":"KassEisler A","year":"1994","journal-title":"Gene Ther"},{"key":"p_51","first-page":"154","volume":"3","author":"KassEisler A","year":"1996","journal-title":"Gene Ther"},{"key":"p_52","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.364-381.2001"},{"key":"p_53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064842"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1038\/374546a0"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.15.9694-9701.2005"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.022"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-36"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00194-2"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)80122-9"},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1993.9.395"},{"key":"p_61","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.05.041"},{"key":"p_62","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.02.020"},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268896007157"},{"key":"p_64","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.06.056"},{"key":"p_65","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00315-6"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.06.037"},{"key":"p_67","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.12.023"},{"key":"p_68","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.2008.78.83","volume":"78","author":"Rosas CT","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"p_69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01706.x"},{"key":"p_70","doi-asserted-by":"publisher","DOI":"10.1038\/297070a0"},{"key":"p_71","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.55.091902.104344"},{"key":"p_72","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23373"},{"key":"p_74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2666-2673.2004"},{"key":"p_75","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200110080-00010"},{"key":"p_76","doi-asserted-by":"publisher","DOI":"10.2174\/1568005033481097"},{"key":"p_77","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4269\/ajtmh.2008.78.328","volume":"78","author":"Turell MJ","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"p_78","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.07.043"},{"key":"p_79","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1526"},{"key":"p_80","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324032"},{"key":"p_81","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.49.061802.123422"},{"key":"p_82","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00526-5"},{"key":"p_83","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050363"},{"key":"p_84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401165101"},{"key":"p_85","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.20.10780-10789.2003"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/vim.2008.0052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:09:35Z","timestamp":1777590575000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/vim.2008.0052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1089\/vim.2008.0052"],"URL":"https:\/\/doi.org\/10.1089\/vim.2008.0052","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}