{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:01:12Z","timestamp":1777878072384,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>\n                    Persistent viruses, such as cytomegalovirus or human immunodeficiency virus, cause major perturbations of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-lymphocyte subpopulations. To test whether chronic infection with hepatitis B virus (HBV) could also be responsible for such modifications, we analyzed the expression of CD27, CD28, CCR7, and perforin in blood CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes. In comparison to healthy subjects and patients recovering from acute hepatitis B, chronic hepatitis B patients showed higher percentages of na\u00efve CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes (CD45RA\n                    <jats:sup>+<\/jats:sup>\n                    CD27\n                    <jats:sup>+<\/jats:sup>\n                    CD28\n                    <jats:sup>+<\/jats:sup>\n                    ), and lower percentages of intermediately-differentiated CD27\n                    <jats:sup>+<\/jats:sup>\n                    CD28\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. The late differentiated CD45RA\n                    <jats:sup>+<\/jats:sup>\n                    CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD28\n                    <jats:sup>\u2212<\/jats:sup>\n                    subset was also present in a large percentage in some patients, but no statistically significant difference with healthy controls was observed. Removal from the circulation of intermediately-differentiated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes may occur during chronic HBV infection, favoring the recruitment of na\u00efve cells. This may result in impairment of the generation of functionally-competent memory cells, and an inability to achieve control of HBV replication.\n                  <\/jats:p>","DOI":"10.1089\/vim.2010.0067","type":"journal-article","created":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T12:39:49Z","timestamp":1297687189000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Reciprocal Changes of Na\u00efve and Effector\/Memory CD8\n                    <sup>+<\/sup>\n                    T Lymphocytes in Chronic Hepatitis B Virus Infection"],"prefix":"10.1177","volume":"24","author":[{"given":"Patrizia","family":"Carotenuto","sequence":"first","affiliation":[{"name":"ErasmusMC","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e8","family":"Artsen","sequence":"additional","affiliation":[{"name":"ErasmusMC","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert D.","family":"Osterhaus","sequence":"additional","affiliation":[{"name":"ErasmusMC","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Pontesilli","sequence":"additional","affiliation":[{"name":"Maasstad Ziekenhuis","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-379"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2004.02.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02919692"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02844-06"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181926c28"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21333"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072076"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0160"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.10.3442"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0302-203"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1407"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00172-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri778"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4342"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.12.7907"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri959"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1254"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.8.1269"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01299-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00271.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118902"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i36.4848"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00356-X"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12423-12434.2002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060995"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.11.5707-5719.2004"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vim.2010.0067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2010.0067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2010.0067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:10:58Z","timestamp":1777590658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vim.2010.0067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1089\/vim.2010.0067"],"URL":"https:\/\/doi.org\/10.1089\/vim.2010.0067","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}