{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:04:43Z","timestamp":1777878283390,"version":"3.51.4"},"reference-count":126,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1089\/vim.2017.0146","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T12:10:55Z","timestamp":1516882255000},"page":"150-158","source":"Crossref","is-referenced-by-count":18,"title":["Opinion: Making Inactivated and Subunit-Based Vaccines Work"],"prefix":"10.1177","volume":"31","author":[{"given":"Brendon Y.","family":"Chua","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia."},{"name":"Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Sekiya","sequence":"additional","affiliation":[{"name":"Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia."},{"name":"Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan."},{"name":"Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.111"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046959"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/363732a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12952-12960.2005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.02.086"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.19"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008761"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603437"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1086\/527489"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08517-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.04.033"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X15000206"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/74719"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011273032204"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.9793"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/2081286a0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063163"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906612"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200822050-00001"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.102"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100486"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01024-15"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.07.012"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.04.030"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.116"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.470-511.2000"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.01.019"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612421114"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nri3694"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4212-4221.2002"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535217"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.11.080"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901474"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.171"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00206-2"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073121"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1086\/498980"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.87"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.01.040"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2306"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445080"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.70"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305584"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.29"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017919305501"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-2659.2008.00038.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000138"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00071-9"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.06.005"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/srep01706"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/326881a0"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2012.78"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401903"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.11.1723"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01633.x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.92"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60419-5"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200800596"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406740101"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70237-2"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001294"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45416"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.58.030603.123625"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.038943-0"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl114"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445127"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00413-10"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69294-5"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202937"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.039"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090247"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nri2510"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200208)32:8<2356::AID-IMMU2356>3.0.CO;2-Z"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/307178a0"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307073090103"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.71"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.81"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.046"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1550"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-421-0_20"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.04.009"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.095"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70296-6"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00538-10"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048180"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600046"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.10.103"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61248-4"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.09.013"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03150100027005"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.11.1853"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/6.8.1235"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03514.x"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103755"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402535"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052122"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00083-0"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.05.018"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3350"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000373"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15014-3"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir447"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.10.005"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1021\/mp300257x"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.001"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100021"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21538"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055778"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02496.x"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/298347a0"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1012004"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819d6394"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000161"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2649"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7833"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.84"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/nature01470"},{"key":"B121","first-page":"6132","volume":"26","author":"Wijayadikusumah AR","year":"2017","journal-title":"Amino Acids"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/289373a0"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.173"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.017"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.10.003"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.04.015"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4905"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.04.004"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90772-4"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/vim.2017.0146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/vim.2017.0146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:16:28Z","timestamp":1777590988000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/vim.2017.0146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/vim.2017.0146"],"URL":"https:\/\/doi.org\/10.1089\/vim.2017.0146","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}