{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:31:09Z","timestamp":1777933869791,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Follicular CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are the main HIV reservoirs due to, among other factors, the low frequency of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in lymphoid follicles. Follicular CXCR5\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are associated with HIV control, but their differentiation conditions are yet undefined. In this study, we explored the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    effect of transforming growth factor (TGF)-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1, interleukin (IL)-12, and IL-23 on the induction of CXCR5, the follicle homing receptor, in human circulating CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from seronegative, and treated HIV-infected individuals. The combination of TGF-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1 plus IL-23 induced the highest expression of CXCR5 in purified CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These CXCR5\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells also expressed a transcriptional and phenotypic profile similar to that of follicular CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, such as the upregulation of\n                    <jats:italic toggle=\"yes\">BCL6<\/jats:italic>\n                    , inducible costimulator and CD40L, and downregulation of\n                    <jats:italic toggle=\"yes\">PRDM1<\/jats:italic>\n                    . These cells responded\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    to CXCL13 and had low expression of CCR7. In addition, after polyclonal stimulation, they produced IL-21, interferon-\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                    perforin. However, in comparison with seronegative individuals, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from HIV-infected patients had a lower response to TGF-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1\/IL-23, a defect that was restored with the blockade of the programmed cell death 1 inhibitory receptor. Thus, TGF-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1 plus IL-23 induce follicular-like CXCR5\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in seronegative individuals, but in HIV-infected patients there is a limited response which could impair the generation of this cell population.\n                  <\/jats:p>","DOI":"10.1089\/vim.2019.0029","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T09:55:48Z","timestamp":1562320548000},"page":"278-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Induction of Follicular-Like CXCR5\n                    <sup>+<\/sup>\n                    CD8\n                    <sup>+<\/sup>\n                    T Cells by TGF-\n                    <i>\u03b2<\/i>\n                    1\/IL-23 Is Limited During HIV Infection"],"prefix":"10.1177","volume":"32","author":[{"given":"Federico","family":"Perdomo-Celis","sequence":"first","affiliation":[{"name":"Grupo Inmunovirolog\u00eda, Facultad de Medicina, Universidad de Antioquia (UdeA), Medell\u00edn, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel G.","family":"Feria","sequence":"additional","affiliation":[{"name":"Grupo Inmunovirolog\u00eda, Facultad de Medicina, Universidad de Antioquia (UdeA), Medell\u00edn, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia A.","family":"Taborda","sequence":"additional","affiliation":[{"name":"Grupo Inmunovirolog\u00eda, Facultad de Medicina, Universidad de Antioquia (UdeA), Medell\u00edn, Colombia."},{"name":"Grupo de Investigaciones Biom\u00e9dicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporaci\u00f3n Universitaria Remington, Medell\u00edn, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Rugeles","sequence":"additional","affiliation":[{"name":"Grupo Inmunovirolog\u00eda, Facultad de Medicina, Universidad de Antioquia (UdeA), Medell\u00edn, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.5.765"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3810"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02507-16"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000860"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2247"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.4.1777"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000314"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401161"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6975"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1715"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.072"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5149"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192845"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96207"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2297"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08798-7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012076"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.4773"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.2.556"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00492"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5099"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19317"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103138"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939412"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/16717"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60104-X"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02168.x"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh383"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016279"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3543"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01332-16"},{"key":"e_1_3_4_34_2","first-page":"006","article-title":"PD-L1\/PD-1 co-stimulation, a brake for T cell activation and a T cell differentiation signal","volume":"12","author":"Liechtenstein T","year":"2012","unstructured":"Liechtenstein T, , Dufait I, , Bricogne C, et al. PD-L1\/PD-1 co-stimulation, a brake for T cell activation and a T cell differentiation signal. J Clin Cell Immunol, 2012; S12:006.","journal-title":"J Clin Cell Immunol"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.5950"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064612"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2009.64"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1610"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1965"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00289"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00296"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122940"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621418114"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003009"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01241"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001700"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2285"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636746"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.075"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00767.x"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117892"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.014"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2947"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3773"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp112"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051113"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.10.012"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1482"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.198.Supp.73.14"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012971"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-045278"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.112"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3229"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000060"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vim.2019.0029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2019.0029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2019.0029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:31:22Z","timestamp":1773246682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vim.2019.0029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1089\/vim.2019.0029"],"URL":"https:\/\/doi.org\/10.1089\/vim.2019.0029","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}