{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:37:10Z","timestamp":1781847430449,"version":"3.54.5"},"reference-count":111,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    Vaccination against\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    -herpesviruses has been hampered by our limited understanding of their normal control. Epstein\u2013Barr virus (EBV)-transformed B cells are killed by viral latency antigen-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , but attempts to block B cell infection with antibody or to prime anti-viral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells have protected poorly\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . The Doherty laboratory used Murid Herpesvirus-4 (MuHV-4) to analyze\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    -herpesvirus control in mice and found CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell dependence, with viral evasion limiting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell function. MuHV-4 colonizes germinal center (GC) B cells via lytic transfer from myeloid cells, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells control myeloid infection. GC colonization and protective, lytic antigen-specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are now evident also for EBV. Subunit vaccines have protected only transiently against MuHV-4, but whole virus vaccines give long-term protection, via CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and antibody. They block infection transfer to B cells, and need include no known viral latency gene, nor any MuHV-4-specific gene. Thus, the Doherty approach of\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    murine analysis has led to a plausible vaccine strategy for EBV and, perhaps, some insight into what CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells really do.\n                  <\/jats:p>","DOI":"10.1089\/vim.2019.0080","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:39:03Z","timestamp":1563878343000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Immune Control of\n                    <i>\u03b3<\/i>\n                    -Herpesviruses"],"prefix":"10.1177","volume":"33","author":[{"given":"Philip G.","family":"Stevenson","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, University of Queensland and Brisbane, Australia."},{"name":"Child Health Research Center, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.6183-6192.2001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.10.015"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.4.567"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12176"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040575197"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030120"},{"key":"e_1_3_3_8_2","first-page":"468","article-title":"M, Svobodov\u00e1 J, and Mistr\u00edkov\u00e1 J. Isolation of five strains of herpesviruses from two species of free living small rodents","volume":"24","author":"Blaskovic D","year":"1980","unstructured":"Blaskovic D, Stancekov\u00e1 M, Svobodov\u00e1 J, and Mistr\u00edkov\u00e1 J. Isolation of five strains of herpesviruses from two species of free living small rodents. Acta Virol, 1980; 24:468.","journal-title":"Acta Virol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19592-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00047-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00213-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-016-0404-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.3.301"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-906"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(97)80019-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.863"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00787-06"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5135"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.09.041"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3154-3161.1999"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005286"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4278-4283.1997"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.9.5247-5252.1993"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.08.020"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071135"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01264-17"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22727"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020890"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19760-0"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003292"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.03.010"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002935"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.88"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01264.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002346"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81577-0"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000705"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001183"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004220"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-063008"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.4.2261-2273.2005"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.01.004"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070256"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.54.10.1699"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.017327-0"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7508"},{"key":"e_1_3_3_47_2","first-page":"e01677","article-title":"The long and complicated relationship between Epstein-Barr virus and epithelial cells","volume":"91","author":"Hutt-Fletcher LM","year":"2016","unstructured":"Hutt-Fletcher LM. The long and complicated relationship between Epstein-Barr virus and epithelial cells. J Virol, 2016; 91:e01677-16.","journal-title":"J Virol"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.21.10142-10152.2000"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1996.0028"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.4.1199"},{"key":"e_1_3_3_51_2","first-page":"101","article-title":"Further isolation of murine herpesviruses from small mammals in southwestern Slovakia","volume":"37","author":"Kozuch O","year":"1993","unstructured":"Kozuch O, , Reichel M, , Lesso J, et al. Further isolation of murine herpesviruses from small mammals in southwestern Slovakia. Acta Virol, 1993; 37:101\u2013105.","journal-title":"Acta Virol"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00100"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61245"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02199-17"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004761"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.12.9849-9857.1999"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.4.1977-1984.1992"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000177"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.13.7308-7318.2003"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2011.01.007"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324794"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.023085-0"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.13.6836-6845.2004"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80588-0"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92297-3"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002986"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.006569-0"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.7.4882-4891.1997"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03614-14"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1593"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.573"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051318"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00863.x"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200212)32:12<3481::AID-IMMU3481>3.0.CO;2-J"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.405"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02700-05"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-107"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.12.4139"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002308"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01306-7"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001048"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636164"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509311102"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.011"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.05.002"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15565"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1059::AID-IMMU1059>3.0.CO;2-L"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9281"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-2-477"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.150240097"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.023507-0"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni818"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02240-08"},{"key":"e_1_3_3_94_2","first-page":"818","article-title":"Lymphoproliferative disease in mice infected with murine \u03b3-herpesvirus 68","volume":"145","author":"Sunil-Chandra NP","year":"1994","unstructured":"Sunil-Chandra NP, , Arno J, , Fazakerley J, , and Nash AA. Lymphoproliferative disease in mice infected with murine \u03b3-herpesvirus 68. Am J Pathol, 1994; 145:818\u2013826.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11553"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02345-14"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006311"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90216-9"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14668-14679.2005"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2015"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5307"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.4.2522-2529.2003"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-8-1971"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-4-627"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.17.8283-8288.2001"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007464"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.03.003"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.014266-0"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-010-8172-z"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480109"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088902"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006905"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vim.2019.0080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2019.0080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2019.0080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:35:51Z","timestamp":1773246951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vim.2019.0080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":111,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1089\/vim.2019.0080"],"URL":"https:\/\/doi.org\/10.1089\/vim.2019.0080","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}