{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:50:20Z","timestamp":1792018220268,"version":"4.4.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    The clinical outcome of dengue is due to a complex interplay between dengue virus (DENV) and host immune factors, including complement and cytokine systems. Proinflammatory cytokines are mainly produced by monocytes in response to infectious pathogens. This study investigated the levels of proinflammatory cytokines, including tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1 beta (IL-1\u03b2), and IL-12 in Vietnamese patients with dengue, and their correlations with the clinical outcome of dengue infection in 156 patients clinically classified as dengue without warning signs (DWS\u2212,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200987), dengue with warning signs (DWS+,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200962), and severe dengue (SD,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097) patients as well as in 60 healthy controls (HCs). Serum TNF-\u03b1, IL-1\u03b2, and IL-12 levels were quantified by enzyme-linked immunosorbent assay (ELISA). The results showed that TNF-\u03b1, IL-1\u03b2, and IL-12 levels were significantly increased in dengue patients compared with HCs (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). TNF-\u03b1 levels were significantly correlated with white blood cells and platelet counts (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    <jats:sub>s<\/jats:sub>\n                    \u2009=\u20090.52, 0.2;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.018, respectively). IL-1\u03b2 levels were correlated with red blood cells counts and the levels of aspartate aminotransferase and alanine aminotransferase (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    <jats:sub>s<\/jats:sub>\n                    \u2009=\u20090.23, 0.21, 0.23;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004, 0.012, 0.005, respectively). The results suggest that these three proinflammatory cytokines are associated with the clinical outcome of dengue and could play roles in the pathogenesis of the disease.\n                  <\/jats:p>","DOI":"10.1089\/vim.2020.0023","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T21:18:01Z","timestamp":1590527881000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Proinflammatory Cytokines Are Modulated in Vietnamese Patients with Dengue Fever"],"prefix":"10.1177","volume":"33","author":[{"given":"Tran Thi","family":"Tuyen","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam."},{"name":"Thai Binh Medical College, Thai Binh, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thanh","family":"Viet","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Thu","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam."},{"name":"Ha Dong Medical College, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Truong","family":"Giang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam."},{"name":"Department of Biology and Medical Genetics, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Duc","family":"Anh","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Tuan","family":"Anh","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Vu","family":"Hung","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do","family":"Quyet","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Linh","family":"Toan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Dinh","family":"Cam","sequence":"additional","affiliation":[{"name":"175 Military Medical Hospital, Ho Chi Minh City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Van Tong","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam."},{"name":"Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.12.027"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-8-86"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001760"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31826fd456"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.142"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3623-3629.1999"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.02.029"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.07.007"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.06.033"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21051"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-341"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2014-09"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00035-09"},{"key":"e_1_3_5_17_2","first-page":"202","article-title":"Role of TNF alpha, IL-6 and CXCL10 in Dengue disease severity","volume":"10","author":"Masood KI","year":"2018","unstructured":"Masood KI, , Jamil B, , Rahim M, et al. Role of TNF alpha, IL-6 and CXCL10 in Dengue disease severity. Iran J Microbiol, 2018; 10:202\u2013207.","journal-title":"Iran J Microbiol"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2019.0100"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","unstructured":"Ooi EE Gubler DJ. Chapter 75\u2014Dengue and dengue hemorrhagic fever. In: Guerrant RL Walker DH Weller PF eds. Tropical Infectious Diseases: Principles Pathogens and Practice. 3rd ed. Edinburgh: W.B. 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