{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:16:13Z","timestamp":1787170573186,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    The dysfunction of memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell cannot be reverted by successful clearance of hepatitis C virus (HCV) after direct-acting antivirals (DAAs) therapy, increasing the risk of reinfection with HCV. Stem cell-like memory T cells (Tscm) with superior properties of long-lasting, self-renewing, and multipotency contribute to the maintenance of immune function. We investigated the impact of HCV infection on CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm, and their possible role in disease progression, by using DAA-naive HCV-infected and human immunodeficiency virus (HIV)\/HCV-coinfected cohorts. The distribution of memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell subsets and the level of T cell immune activation were determined by flow cytometry. Associations between CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm and other memory T cell subsets, HCV viral load, as well as the level of T cell immune activation were analyzed. We observed that the proportion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm increased in both HCV and HIV\/HCV individuals. The proportion of CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm had positive and negative correlation with CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tcm (central memory T cells) and CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tem (effector memory T cell), respectively, representing the contribution of CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm in T cell homeostasis. In addition, higher frequency of CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm indicated lower HCV viral load and less T cell immune activation in HCV infection, which suggested that CD8\n                    <jats:sup>+<\/jats:sup>\n                    Tscm is likely associated with effective control of HCV replication for protective immunity. Considering the characteristics of Tscm, our current findings provide implications for Tscm-based vaccine design and immunotherapy development to achieve HCV elimination.\n                  <\/jats:p>","DOI":"10.1089\/vim.2022.0079","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:54:45Z","timestamp":1667904885000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of CD8\n                    <sup>+<\/sup>\n                    Stem Cell-Like Memory T Cell Subset in Chronic Hepatitis C Virus Infection"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-0242","authenticated-orcid":false,"given":"Xiaofan","family":"Lu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, China."},{"name":"Department of Dermatology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen Ka Loon","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Hong Kong Baptist University, Hong Kong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for HIV\/AIDS Research, Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, 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