{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:29:57Z","timestamp":1774020597336,"version":"3.50.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    To study the clinical significance of manganese (Mn) in the serum of children with infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) infection, we analyzed the correlation between Mn and the cyclic GMP-AMP synthase (cGAS)\u2013stimulator of interferon genes (STING) pathway and explored the immune pathogenesis of EBV infection. Children diagnosed with IM comprised the IM group, and healthy children during the same period were selected as the normal control group. Real-time reverse transcription-polymerase chain reaction was used to detect the mRNA expression levels of\n                    <jats:italic toggle=\"yes\">cGAS, STING<\/jats:italic>\n                    , Tank-binding kinase 1 (\n                    <jats:italic toggle=\"yes\">TBK1<\/jats:italic>\n                    ), interferon regulatory factor 3 (\n                    <jats:italic toggle=\"yes\">IRF3<\/jats:italic>\n                    ), and related inflammatory factors, and Mn in serum was detected by inductively coupled plasma mass spectrometry. Interferon (IFN)-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    and IFN-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    expression levels in serum were detected by enzyme-linked immunosorbent assay, and the correlation between Mn levels and clinical manifestations and laboratory tests was analyzed. Mn levels and the expression levels of\n                    <jats:italic toggle=\"yes\">cGAS, STING<\/jats:italic>\n                    , and related inflammatory factors were significantly higher in children with IM than in healthy children. Furthermore, Mn levels in children with IM were positively correlated with the expression levels of\n                    <jats:italic toggle=\"yes\">cGAS<\/jats:italic>\n                    and related inflammatory factor\n                    <jats:bold>s<\/jats:bold>\n                    . Thus, Mn,\n                    <jats:italic toggle=\"yes\">cGAS, STING<\/jats:italic>\n                    , and inflammatory cytokines may be involved in the immune mechanism of IM caused by EBV infection.\n                  <\/jats:p>","DOI":"10.1089\/vim.2022.0108","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T16:23:58Z","timestamp":1670603038000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Manganese and the cGAS\u2013STING Pathway in Infectious Mononucleosis Caused by Epstein-Barr Virus Infection"],"prefix":"10.1177","volume":"36","author":[{"given":"Jinjin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China."},{"name":"Department of Internal Medicine, Children's Hospital of Wujiang District, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-4977","authenticated-orcid":false,"given":"Weifang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0578-1310.2016.08.002"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.04.006"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0198-7"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-7230-7_22"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.04.071"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.001"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500300n"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.08.025"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095388"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.11816\/cn.ni.2021-202371"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.13493\/j.issn.1672-7878.2017.08-026"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0837"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00445-07"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01375.x"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.12037\/YXQY.2019.11-10"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09049-x"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00242h"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101215"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1003-515X.2012.16.017"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.058040-0"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.01.010"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129710"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.10.008"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008762"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.017"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-9572.2017.17.010"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.11844\/cjcb.2020.10.0001"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845413Y.0000000084"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1000-2"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00669-w"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/vim.2022.0108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2022.0108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/vim.2022.0108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:37:08Z","timestamp":1773247028000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/vim.2022.0108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1089\/vim.2022.0108"],"URL":"https:\/\/doi.org\/10.1089\/vim.2022.0108","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}