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In this study, we conducted a meta-analysis of all currently published literature on the efficacy and safety of the MVA\u2013BN vaccine in the real world, showing that the MVA\u2013BN vaccine is effective and safe, with efficacy of up to 75% with a single dose and up to 80% with a two-dose vaccine. Meanwhile, we found that subcutaneous injection has lower local and systemic adverse events than intradermal injection, regardless of single- or two-dose vaccination, and subcutaneous injection is better tolerated in children, the elderly, or people with underlying medical conditions. These results have important reference value for clinical practice.<\/jats:p>","DOI":"10.1089\/vim.2023.0147","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T11:59:06Z","timestamp":1715169546000},"page":"216-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Safety and Efficacy of the Modified Vaccinia Ankara\u2013Bavaria Nordic Vaccine Against Mpox in the Real World: Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"37","author":[{"given":"Yi","family":"Pang","sequence":"first","affiliation":[{"name":"Science and Technology Department, Youjiang Medical University for Nationalities, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Long","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Tian","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xidai","family":"Long","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6918-2779","authenticated-orcid":false,"given":"Yulei","family":"Li","sequence":"additional","affiliation":[{"name":"Clinicopathological Diagnosis &amp; Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China."},{"name":"Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(23)00057-9"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7220a3"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.7683"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215201"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2215846"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(23)00270-0"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11071163"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.Es.2023.28.24.2200883"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7220a4"},{"key":"e_1_3_4_11_1","unstructured":"US Food & Drug Administration. 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