{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:37Z","timestamp":1787755357419,"version":"build-2784847793"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Objective:<\/jats:title>\n A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking.<\/jats:p>\n <\/jats:sec>\n \n Approach:<\/jats:title>\n \n This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799\u2009VLUs) receiving treatment at 177 wound care centers. Ulcers \u226528 days duration, between \u22651 and <\u200940\u2009cm\n 2<\/jats:sup>\n that closed \u226440% within the 28 days before treatment were included.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Patient baseline demographics and wound characteristics were comparable between groups. The median time to wound closure was 52% faster with BLCC compared with CCSA (15 weeks vs. 31 weeks). In addition, the proportion of wounds healed were significantly higher for BLCC by 12 weeks (42% vs. 24%) and 24 weeks (65% vs. 41%) (\n p<\/jats:italic>\n \u2009=\u20090.0002). Treatment with BLCC increased the probability of healing by 97% compared with CCSA (hazard ratio\u2009=\u20091.97 [95% confidence interval 1.39\u20132.79],\n p<\/jats:italic>\n \u2009=\u20090.0002).\n <\/jats:p>\n <\/jats:sec>\n \n Innovation:<\/jats:title>\n This is the first real-world comparative effectiveness analysis to evaluate BLCC and CCSA for the treatment of VLUs.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Treatment with a bioengineered cellular technology significantly improved the incidence and speed of wound closure compared with a CCSA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/wound.2017.0738","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T12:10:24Z","timestamp":1513944624000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative Effectiveness of a Bioengineered Living Cellular Construct and Cryopreserved Cadaveric Skin Allograft for the Treatment of Venous Leg Ulcers in a Real-World Setting"],"prefix":"10.1177","volume":"7","author":[{"given":"Terry","family":"Treadwell","sequence":"first","affiliation":[{"name":"Institute for Advanced Wound Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Sabolinski","sequence":"additional","affiliation":[{"name":"Sabolinski LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Skornicki","sequence":"additional","affiliation":[{"name":"Organogenesis, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan B.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Organogenesis, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70295-D"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCQ.0000347447.05924.db"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02456.x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"key":"e_1_3_4_6_2","first-page":"38","article-title":"Painful venous ulcers: themes and stories about their impact on quality of life","volume":"44","author":"Krasner D","year":"1998","unstructured":"Krasner D. Painful venous ulcers: themes and stories about their impact on quality of life. Ostomy Wound Manage, 1998; 44:38\u201349.","journal-title":"Ostomy Wound Manage"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70134-2"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2009.14.Sup6.45538"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.903258"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6584.1389"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012207.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.8.920"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19629.x"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.293"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1938640010387417"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000489991.32684.9e"},{"key":"e_1_3_4_19_2","unstructured":"Net Health. http:\/\/nethealth.com\/products\/wound-care\/woundexpert-software-wound-care-ehr (last accessed December27 2016)."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3248"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4733.2003.00242.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1324"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2009.00600.x"},{"key":"e_1_3_4_24_2","unstructured":"Velentgas P Dreyer NA Nourjah P Smith SR Torchia MM editors. 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