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Hyperglycemia from diabetes and oxidative stress from ischemia activate polyadenosine diphosphate (ADP)-ribose polymerase-1 (PARP-1), which is a nuclear enzyme that is best known for its role in DNA repair. However, the exact function of PARP-1 in ischemic\/diabetic wound healing has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>Poly-ADP-ribose (PAR) polymer has been detected in the wound bed and many of the PARylation-related reactions (oxidative stress response, expression of inflammatory cytokines and chemokines, cell proliferation, and migration) are important in the wound healing process. However, the role of PARP-1 in wound healing and the potential of targeting PARP-1 therapeutically in wounds are only recently being elucidated, with much still unknown. This review summarizes the recent advances in this field, highlighting some of the mechanisms through which PARP-1 may affect normal wound closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>The review also presents a perspective on some of the downstream targets of PARP-1 that may be explored for their role in wound healing and discusses about the therapeutic potential of PARP inhibitors for wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2018.0821","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T11:23:00Z","timestamp":1556277780000},"page":"634-643","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Poly(ADP-Ribose) Polymerase-1 in Cutaneous Wound Healing"],"prefix":"10.1177","volume":"8","author":[{"given":"Jaideep","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, George Washington University, Washington, District of Columbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niraj","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Hackensack University Medical Center, Hackensack, New Jersey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, George Washington University, Washington, District of Columbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5439521"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.157"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.060"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20085"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3420249"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1003-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2008.03.006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.017"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183509.111"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006983304079"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.053"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009897200"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202406"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.296"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2261"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7621"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.118"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3240249"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00131-8"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.3.866"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.48.31644"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3423"},{"key":"e_1_3_4_26_2","first-page":"8878","article-title":"The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin","volume":"264","author":"Huletsky A","year":"1989","unstructured":"Huletsky A, , de Murcia G, , Muller S, et al. 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