{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:11:17Z","timestamp":1781763077513,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>We determined the single time point concentration of timolol in plasma 1\u2009h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2019.0970","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T15:30:38Z","timestamp":1562686238000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds"],"prefix":"10.1177","volume":"8","author":[{"given":"Anthony Cole","family":"Gallegos","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California Davis School of Medicine, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael James","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California Davis School of Medicine, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine N.","family":"Tchanque-Fossuo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California Davis School of Medicine, Sacramento, California."},{"name":"Dermatology Service; Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"West","sequence":"additional","affiliation":[{"name":"Dermatology Service; Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Eisentrout-Melton","sequence":"additional","affiliation":[{"name":"Dermatology Service; Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Peavy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University, Sacramento, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy W.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, California State University, Sacramento, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Ophthalmology Service; Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."},{"name":"UC Davis Health System Eye Center, UC Davis School of Medicine, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Evona","family":"Dahle","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California Davis School of Medicine, Sacramento, California."},{"name":"Podiatry Section, Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn Rivkah","family":"Isseroff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California Davis School of Medicine, Sacramento, California."},{"name":"Dermatology Service; Department of Surgery; VA Northern California, Sacramento VA Medical Center, Mather, California."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0946"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.06.003"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02200.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.04.019"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450040067008"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017962731813"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.08.016"},{"key":"e_1_3_5_9_2","unstructured":"U.S. National Library of Medicine. Beta adrenergic antagonist for the healing of chronic DFU (BAART-DFU). ClinicalTrials.gov 2018; https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03282981?term=NCT03282981&rank=1 (last accessed December30 2018)."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2016.1225718"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.370"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.07.012"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000012"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.137"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19611.x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300205200"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4188com"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20934"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130408.x"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.415"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.108"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0473"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.7135"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.5070\/D3203021726"},{"key":"e_1_3_5_25_2","first-page":"924","article-title":"Topical 0.5% timolol heals a recalcitrant irradiated surgical scalp wound","volume":"40","author":"Beroukhim K","year":"2014","unstructured":"Beroukhim K, , Rotunda AM. Topical 0.5% timolol heals a recalcitrant irradiated surgical scalp wound. Dermatol Surg, 2014; 40:924\u2013926.","journal-title":"Dermatol Surg"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.060"},{"key":"e_1_3_5_27_2","unstructured":"U.S. National Library of Medicine. Beta Adrenergic antagonist for the healing of chronic DFU. ClinicalTrials.gov 2018; https:\/\/clinicaltrials.gov\/ct2\/results?cond=&term=NCT03282981&cntry=&state=&city=&dist=(last accessed December13 2018)."},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14566"},{"key":"e_1_3_5_29_2","first-page":"E17","article-title":"Expanding uses of propranolol in dermatology","volume":"99","author":"Oberlin KE.","year":"2017","unstructured":"Oberlin KE. Expanding uses of propranolol in dermatology. Cutis, 2017; 99:E17\u2013E19.","journal-title":"Cutis"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_220_16"},{"key":"e_1_3_5_31_2","unstructured":"U.S.. National Library of Medicine. Clinical trials search term timolol and skin. ClinicalTrials.gov 2018; https:\/\/clinicaltrials.gov\/ct2\/results?pg=1&load=cart&id=NCT02774590+OR+NCT02422017+OR+NCT03452072+OR+NCT03579160+OR+NCT03282981 (last accessed December12 2018)."},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01685.x"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-2-197"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S118409"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34141-0"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00608402"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1993.9.373"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3828"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2009.04.017"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15865"},{"key":"e_1_3_5_41_2","unstructured":"U.S. National Library of Medicine. Efficacy safety and pharmacokinetics of topical timolol in infants with infantile hemangioma. ClinicalTrials.gov 2018; https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02913612 (last accessed December13 2019)."},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12267"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80048-5"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198503000-00006"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13189"},{"key":"e_1_3_5_46_2","volume-title":"Clinical Ocular Pharmacology","author":"Bartlett J","year":"2007","unstructured":"Bartlett J, , Jaanas S. Clinical Ocular Pharmacology, 5th ed., Oxford, United Kingdom: Butterworth-Heinemann, 2007.","edition":"5"}],"container-title":["Advances in Wound Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/wound.2019.0970","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.0970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.0970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:17:24Z","timestamp":1773238644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/wound.2019.0970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1089\/wound.2019.0970"],"URL":"https:\/\/doi.org\/10.1089\/wound.2019.0970","relation":{},"ISSN":["2162-1918","2162-1934"],"issn-type":[{"value":"2162-1918","type":"print"},{"value":"2162-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,16]]}}}