{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:44:03Z","timestamp":1773305043568,"version":"3.50.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In recent years, reticulated open-cell foam-based closed-incision negative pressure therapy (ROCF-ciNPT) has shown effectiveness in management of various postoperative incisions. These dressings consist of a skin interface layer that absorbs fluid from the skin surface and reduces the potential for microbial colonization within the dressing by means of ionic silver. This study examines the ability of silver to reduce the bioburden within the dressing as well as the localized effect due to potential silver mobility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>\n                      Ability of silver to reduce bioburden within the ROCF-ciNPT dressing was assessed using\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      spp. Furthermore, silver mobility was assessed using an\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      skin model to study the zone of inhibition along with released silver quantification. Using a porcine model, diffusion of silver into blood and tissue was studied using emission spectrometry and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Microbial growth in the ROCF-ciNPT dressing was significantly reduced (\u223c2.7\u20134.9 log reduction) compared to a silver-free negative control. No zone of inhibition was observed for microbial colonies for up to 7 days with minimal localized silver release (&lt;5.5\u2009ppm release).\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      studies demonstrated no measurable concentration (&lt;0.2\u2009\u03bcg\/g) of silver in the blood, urine, feces, kidney, and liver tissue biopsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This study provides an important insight into silver concentration and mobility within the ROCF-ciNPT dressing, given emerging concerns associated with potential silver cytotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results indicate the concentration of silver (0.019% silver by weight) in the ROCF-ciNPT dressings has been adequate to reduce bioburden within the skin interface layer, while severely limiting the amount of silver leaching out.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2019.0997","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:39:58Z","timestamp":1563878398000},"page":"462-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Silver Levels in a Closed-Incision Negative Pressure Therapy Dressing:\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Study"],"prefix":"10.1177","volume":"9","author":[{"given":"Prathamesh M.","family":"Kharkar","sequence":"first","affiliation":[{"name":"KCI USA, Inc., An Acelity Company, San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra N.","family":"Osborne","sequence":"additional","affiliation":[{"name":"KCI USA, Inc., An Acelity Company, San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scout L.","family":"Stern","sequence":"additional","affiliation":[{"name":"KCI USA, Inc., An Acelity Company, San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Pleitner","sequence":"additional","affiliation":[{"name":"Food Safety Net Services, Inc., San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Mark","family":"Wiencek","sequence":"additional","affiliation":[{"name":"Milliken Healthcare, Spartanburg, South Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine M.","family":"Kieswetter","sequence":"additional","affiliation":[{"name":"KCI USA, Inc., An Acelity Company, San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30398-X"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005305"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.03.065"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.4663"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.03.021"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005312"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005306"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005310"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005308"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.05.224"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2008.09.002"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/2228-5326-2-32"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.11.016"},{"key":"e_1_3_5_16_2","article-title":"A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices","volume":"2010","author":"Lansdown AB.","year":"2010","unstructured":"Lansdown AB. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci, 2010; 2010:910686.","journal-title":"Adv Pharmacol Sci"},{"key":"e_1_3_5_17_2","first-page":"307","article-title":"Exploring the effects of silver in wound management: what is optimal?","volume":"18","author":"White R","year":"2006","unstructured":"White R, , Cutting K. Exploring the effects of silver in wound management: what is optimal?. Wounds, 2006; 18:307\u2013314.","journal-title":"Wounds"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/nano.2006.1.4.441"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12049"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.2109\/jcersj2.116.767"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.141"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.11.019"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.11.036"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00190.x"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15055"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12235"},{"key":"e_1_3_5_27_2","first-page":"1","article-title":"Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function","volume":"33","author":"Boer M","year":"2016","unstructured":"Boer M, , Duchnik E, , Maleszka R, , Marchlewicz M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Postepy Dermatol Alergol, 2016; 33:1\u20135.","journal-title":"Postepy Dermatol Alergol"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00410.x"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205923"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.4.26596"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659609020246"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-014-0339-x"},{"key":"e_1_3_5_33_2","first-page":"308","article-title":"Negative pressure therapy for closed spine incisions: a pilot study","volume":"24","author":"Glaser DA","year":"2012","unstructured":"Glaser DA, , Farnsworth CL, , Varley ES, et al. Negative pressure therapy for closed spine incisions: a pilot study. Wounds, 2012; 24:308\u2013316.","journal-title":"Wounds"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn302649p"},{"key":"e_1_3_5_35_2","first-page":"1415","article-title":"Comparative metabolism of radionuclides in mammals","volume":"12","author":"Furchner JE","year":"1966","unstructured":"Furchner JE, , Richmond CR, , Drake GA. Comparative metabolism of radionuclides in mammals. 3. Retention of manganese-54 in the mouse, rat, monkey and dog. Health Phys, 1966; 12:1415\u20131423.","journal-title":"3. Retention of manganese-54 in the mouse, rat, monkey and dog. Health Phys"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-8-18"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000493"}],"container-title":["Advances in Wound Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/wound.2019.0997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.0997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.0997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:13:28Z","timestamp":1773238408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/wound.2019.0997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1089\/wound.2019.0997"],"URL":"https:\/\/doi.org\/10.1089\/wound.2019.0997","relation":{},"ISSN":["2162-1918","2162-1934"],"issn-type":[{"value":"2162-1918","type":"print"},{"value":"2162-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]}}}