{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:47:10Z","timestamp":1790632030247,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>Impaired dermal wound healing represents a major medical issue in today's aging populations. Granulation tissue formation in the dermis and reepithelization of the epidermis are both important and necessary for proper wound healing. Although a number of artificial dermal grafts have been used to treat full-thickness dermal loss in humans, they do not induce reepithelization of the wound, requiring subsequent epithelial transplantation. In the present study, we sought a novel biomaterial that accelerates the wound healing process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>We prepared a composite biomaterial made of jellyfish and porcine collagens and developed a hybrid-type dermal graft that composed of the upper layer film and the lower layer sponge made of this composite biomaterial. Its effect on dermal wound healing was examined using a full-thickness excisional wound model. Structural properties of the dermal graft and histological features of the regenerating skin tissue were characterized by electron microscopic observation and immunohistological examination, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The composite biomaterial film stimulated migration of keratinocytes, leading to prompt reepithelization. The regenerating epithelium consisted of two distinct cell populations: keratin 5-positive basal keratinocytes and more differentiated cells expressing tight junction proteins such as claudin-1 and occludin. At the same time, the sponge made of the composite biomaterial possessed a significantly enlarged intrinsic space and enhanced infiltration of inflammatory cells and fibroblasts, accelerating granulation tissue formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This newly developed composite biomaterial may serve as a dermal graft that accelerates wound healing in various pathological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We have developed a novel dermal graft composed of jellyfish and porcine collagens that remarkably accelerates the wound healing process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2019.1014","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T11:14:42Z","timestamp":1570101282000},"page":"295-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["A Novel Composite Biomaterial Made of Jellyfish and Porcine Collagens Accelerates Dermal Wound Healing by Enhancing Reepithelization and Granulation Tissue Formation in Mice"],"prefix":"10.1177","volume":"9","author":[{"given":"Hideaki","family":"Sumiyoshi","sequence":"first","affiliation":[{"name":"Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan."},{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachie","family":"Nakao","sequence":"additional","affiliation":[{"name":"Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan."},{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayo","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan."},{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan."},{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Okamura","sequence":"additional","affiliation":[{"name":"Course of Industrial Chemistry, Graduate School of Engineering, Tokai University, Hiratsuka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira T.","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Japan."},{"name":"Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan."},{"name":"Instutute of Medical Sciences, Tokai University, Isehara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00438.x"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00306-4"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.5.1333"},{"key":"e_1_3_5_7_2","first-page":"1459","article-title":"et al","volume":"137","author":"Higashiyama R","year":"2009","unstructured":"Higashiyama R, , Moro T, , Nakao S K. et al. Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology, 2009; 137:1459\u20131466.","journal-title":"Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.314"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.03.002"},{"key":"e_1_3_5_10_2","first-page":"83","volume-title":"Rubin's Pathology, Clinicopathologic Foundations of Medicine","author":"Sephel GC","year":"2012","unstructured":"Sephel GC, , Davidson JM. Repair, regeneration and fibrosis. In: Rubin R, , Strayer DS, , Rubin E, eds. Rubin's Pathology, Clinicopathologic Foundations of Medicine, 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins, 2012:83\u2013114.","edition":"6"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0844-4"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801651"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820140108"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820270111"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.231"},{"key":"e_1_3_5_16_2","first-page":"413","article-title":"Jung WK","volume":"194","author":"Burke JF","year":"1981","unstructured":"Burke JF, , Yannas IV, , Quinby WC, , Bondoc CC. Jung WK. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg, 1981; 194:413\u2013427.","journal-title":"Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2015.1046367"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.10.022"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-014-1652-8"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33959"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-011-9371-8"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.11.003"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)82059-4"},{"key":"e_1_3_5_24_2","first-page":"913","article-title":"Demiate, Collagen extraction process","volume":"23","author":"Schmidt MM","year":"2016","unstructured":"Schmidt MM, , Dornelles RCP, , Mello RO, et al. Demiate, Collagen extraction process. Int Food Res J, 2016; 23:913\u2013912.","journal-title":"Int Food Res J"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(83)80020-X"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.03.011"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820140417"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9345"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21477"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2916"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(00)00043-3"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.3.381"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12387.x"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.11.021"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.01.002"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.02.006"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.12.008"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.3800\/pbr.3.125"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12562-009-0114-0"},{"key":"e_1_3_5_40_2","first-page":"337","article-title":"Blooms and population dynamics of moon jellyfish in the northern Adriatic","volume":"53","author":"Malej A","year":"2012","unstructured":"Malej A, , Kogovsek T, , Ramsak A, et al. Blooms and population dynamics of moon jellyfish in the northern Adriatic. Cah Biol Mar, 2012; 53:337\u2013342.","journal-title":"Cah Biol Mar"}],"container-title":["Advances in Wound Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/wound.2019.1014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.1014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2019.1014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:22:27Z","timestamp":1773238947000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/wound.2019.1014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1089\/wound.2019.1014"],"URL":"https:\/\/doi.org\/10.1089\/wound.2019.1014","relation":{},"ISSN":["2162-1918","2162-1934"],"issn-type":[{"value":"2162-1918","type":"print"},{"value":"2162-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}