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Current literature demonstrates the importance of expanding the knowledge of all prosthetic device-specific factors and the significance of proper prescription, fit, and alignment, along with adequate device-\/activity-specific training, to enhance human\u2013device interaction, reduce gait abnormalities and compensatory motions, and as a result, mitigate risk for secondary musculoskeletal conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>Inadequate device prescription, fit, alignment, and training are evident owing to the lack of knowledge or awareness of the many device-specific properties and factors, leading to suboptimal use, as well as, biomechanical compensations, which collectively and adversely affect the function, activity level, and overall health of the prosthesis user.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>To maximize optimal outcomes after lower limb loss, it is essential to better appreciate the factors that affect both prosthesis use and satisfaction, particularly any modifiable factors that might be targeted in rehabilitation interventions such as device prescription, fit\/alignment, and training regimes. A better understanding of such device-specific factors will help enhance the human\u2013device interaction and resulting functional performance, thereby reducing secondary musculoskeletal conditions, allowing for the readiness of the fighting force (return-to-duty\/redeployment) and\/or improved reintegration into civilian society\/work, and overall enhancing quality of life after lower limb loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2019.1079","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T12:15:06Z","timestamp":1587557706000},"page":"671-684","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Deleterious Musculoskeletal Conditions Secondary to Lower Limb Loss: Considerations for Prosthesis-Related Factors"],"prefix":"10.1177","volume":"10","author":[{"given":"Ashley D.","family":"Knight","sequence":"first","affiliation":[{"name":"DoD-VA Extremity Trauma &amp; Amputation Center of Excellence, Bethesda, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Dearth","sequence":"additional","affiliation":[{"name":"DoD-VA Extremity Trauma &amp; Amputation Center of Excellence, Bethesda, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad D.","family":"Hendershot","sequence":"additional","affiliation":[{"name":"DoD-VA Extremity Trauma &amp; Amputation Center of Excellence, Bethesda, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.11.010"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.11.005"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.21300\/18.2-3.2016.99"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0714"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2006.11.0147"},{"key":"e_1_3_4_7_2","first-page":"1","article-title":"Back pain and osteoarthritis as secondary disabilities of lower limb amputation","volume":"1","author":"Pr\u00f6bsting E","year":"2018","unstructured":"Pr\u00f6bsting E, , Kannenberg A, , Blumentritt S. 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