{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:34:10Z","timestamp":1793036050380,"version":"4.5.0"},"reference-count":64,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>Prolonged inflammation and impaired angiogenesis are the two principal factors that prevent successful wound healing, which is exacerbated in people with diabetes. There is a significant need for new wound healing treatments that target both these factors simultaneously. This review discusses the emerging evidence that high-density lipoproteins (HDL) have pleiotropic wound healing benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Numerous\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies have demonstrated the anti-inflammatory and proangiogenic effects of HDL. In endothelial cells, HDL mediate these effects through interaction with the scavenger receptor SR-BI, which activates the PI3K\/Akt pathway, causing a decrease in inflammatory protein production and an increase in proangiogenic growth factors. In macrophages, HDL inhibit inflammation through suppression of the nuclear factor kappa B activation pathway. This review details the molecular disturbances that cause impaired wound healing in diabetes with a particular focus on inflammation and angiogenesis and the pathways in which HDL provide benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>Diabetic foot ulcers (DFUs) impose a major public health challenge worldwide. It is estimated that 20% patients with DFUs require amputation, which is accompanied by a significant social and economic burden. To date, there are no therapeutic agents with pleiotropic effects that actively improve wound healing, highlighting a therapeutic void for this complex disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2020.1308","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T01:35:17Z","timestamp":1605144917000},"page":"370-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["The Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing"],"prefix":"10.1177","volume":"10","author":[{"given":"Zahra","family":"Lotfollahi","sequence":"first","affiliation":[{"name":"Vascular Research Centre, South Australian Health and Medical Research Institute, Adelaide, Australia."},{"name":"Faculty of Health and Medical Science, The University of Adelaide, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Dawson","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, and The University of Adelaide, Adelaide, Australia."},{"name":"Department of Vascular and Endovascular Surgery, Royal Adelaide Hospital, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fitridge","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, and The University of Adelaide, Adelaide, Australia."},{"name":"Department of Vascular and Endovascular Surgery, Royal Adelaide Hospital, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bursill","sequence":"additional","affiliation":[{"name":"Vascular Research Centre, South Australian Health and Medical Research Institute, Adelaide, Australia."},{"name":"Faculty of Health and Medical Science, The University of Adelaide, Adelaide, Australia."},{"name":"ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), The University of Adelaide, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.002"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14436"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1471"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01773.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2707"},{"key":"e_1_3_4_9_2","first-page":"5A","article-title":"Cholesterol and lipids in the risk of coronary artery disease\u2014the Framingham Heart Study","volume":"4","author":"Castelli WP","year":"1988","unstructured":"Castelli WP. 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