{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:41:31Z","timestamp":1788493291092,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study sought to examine the real-world impact of multimodality cyclical-pressure topical wound oxygen therapy (TWO2) on hospitalizations and amputations in patients with diabetic foot ulcer (DFU) compared with patients without TWO2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective review of deidentified patient medical records at 2 U.S. Veterans Affairs hospitals between January 2012 and January 2020. DFU patients were assigned to TWO2 or NO TWO2 cohorts based on their treatment records. Patients received appropriate standard of care and may have received other advanced wound treatments, including skin substitutes, negative pressure wound therapy, and growth factors. Primary study outcomes were patients requiring hospitalization and\/or amputation within 360 days of initial wound documentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>\n                      Among unmatched cohorts of 202 patients with DFU (91 TWO2, 111 NO TWO2), 6.6% and 12.1% of TWO2 patients had hospitalizations and amputations, respectively, compared with 54.1% and 41.4% of NO TWO2 patients within 360 days (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), representing 88% and 71% reductions. Among propensity score-matched cohorts of 140 DFU patients (70 TWO2, 70 NO TWO2), compared with NO TWO2, 82% fewer TWO2 patients were hospitalized (7.1% vs. 40.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and 73% fewer TWO2 patients had amputations (8.6% vs. 31.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0007). Logistic regression among matched cohorts demonstrated nearly ninefold and fivefold higher risk of hospitalization and amputation, respectively, for NO TWO2 versus TWO2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation:<\/jats:title>\n                    <jats:p>This retrospective cohort study demonstrates that treating patients with DFU with TWO2 is associated with significant reductions in hospitalizations and amputations in the real-world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2021.0118","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T10:34:32Z","timestamp":1635503672000},"page":"657-665","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes"],"prefix":"10.1177","volume":"11","author":[{"given":"Jessica Izhakoff","family":"Yellin","sequence":"first","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Gaebler","sequence":"additional","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Niecko","sequence":"additional","affiliation":[{"name":"Niecko Health Economics LLC, Tierra Verde, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Novins","sequence":"additional","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Ockert","sequence":"additional","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Krzynowek","sequence":"additional","affiliation":[{"name":"Health Advances LLC, Newton, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Garoufalis","sequence":"additional","affiliation":[{"name":"Department of Podiatry, Jesse Brown VA Medical Center, Chicago, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliza M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Podiatry, Salem Veterans Affairs Medical Center, Salem, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-303X","authenticated-orcid":false,"given":"Robert G.","family":"Frykberg","sequence":"additional","affiliation":[{"name":"Department of Podiatry, Diabetic Foot Consultants, Midwestern University, Glendale, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1836"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","unstructured":"Armstrong DG Swerdlow MA Armstrong AA Conte MS Padula WV Bus SA. Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res [Internet] 2020 Mar 24 [cited 2021 Mar 18];13. 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Missing Data in Clinical Studies. John Wiley & Sons; 2007. 529 p.","DOI":"10.1002\/9780470510445"},{"key":"e_1_3_5_18_2","unstructured":"The PSMATCH Procedure. In: SAS\/STAT\u00ae 142 User's Guide [Internet]. Cary NC: SAS Institute Inc; Available from: https:\/\/support.sas.com\/documentation\/onlinedoc\/stat\/142\/psmatch.pdf"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1850"},{"key":"e_1_3_5_20_2","unstructured":"Margolis DJ Malay DS Hoffstad O et al. Economic burden of diabetic foot ulcers and amputations. Diabetic Foot Ulcers Data Points #3 (prepared by the University of Pennsylvania DEcIDE Center under Contract No HHSA290200500411). 2011 Jan;AHRQ Publication No. 10(11)-EHC009-2-EF."},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2013.11.0249"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0729"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.Sup9.S30"},{"key":"e_1_3_5_24_2","first-page":"24","article-title":"Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study","volume":"56","author":"Blackman E","year":"2010","unstructured":"Blackman E, , Moore C, , Hyatt J, , Railton R, , Frye C. Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study. 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